Synthesis,Characterization and Evaluation of the Anticancer and Antimicrobial Activities of Some Novel Benzazole and Benzazine Derivatives

Authors

  • Wesam Saber Shehab Zagazig universty
  • Naglaa Z.H. Eleiwa Zagazig University, Zagazig
  • Samar.M. Mouneir Cairo University, Cairo

DOI:

https://doi.org/10.24297/jac.v3i3.927

Keywords:

Diamine, benzotriazepine, benzotriazole, benzimidazole, benzothiadiazine, anticancer and antimicrobial activities

Abstract

The present study was designed to synthesize  and develop new useful lead compounds (some novel benzazole and benzazine derivatives ) of simple structure , exhibiting optimal in vitro anticancer  and antimicrobial potency. Phenylenediamine derivative 1 was condensed  with  dithiocarboxylic acid derivatives 2 and produced   benzimidazole derivative 4. The benzotriazepines 8 and 10  were formed by the reaction of 1 with dicarbonyl derivatives followed by intermolecular coupling reaction. The synthesis of benzotriazine12, benzotriazole 14,17, benzimidazole16 and benzothiadiazine 19 from compound 1 was also described. The Synthesized Compounds were characterized by Spectral Studies like IR, H1 – NMR and Analysis Spectra .The title compounds were screened for their possible In vitro anticancer and antimicrobial activities. Among the synthesized compounds, some have shown promisingly remarkable activities against  different  cancer cell lines (MCF-7 human breast cancer cells, HepG2 human hepatocarcinoma cells and PC3 human prostate cancer cells)and moderate  to high antibacterial and antifungal activities. The obtained results showed that the most active compounds could be useful as a template for future design, modification and investigation to produce more active analogs.

Downloads

Download data is not yet available.

Author Biographies

Wesam Saber Shehab, Zagazig universty

Department of Chemistry-Faculty of ScienceFaculty of Clinical Pharmacy, Taif University, Taif, KSA

Naglaa Z.H. Eleiwa, Zagazig University, Zagazig

Department of Pharmacology, Faculty of Veterinary Medicine

Samar.M. Mouneir, Cairo University, Cairo

Department of Pharmacology, Faculty of Veterinary MedicineFaculty of Clinical Pharmacy, Taif University, Taif, KSA 

Downloads

Published

2007-12-05

How to Cite

Shehab, W. S., Eleiwa, N. Z., & Mouneir, S. (2007). Synthesis,Characterization and Evaluation of the Anticancer and Antimicrobial Activities of Some Novel Benzazole and Benzazine Derivatives. JOURNAL OF ADVANCES IN CHEMISTRY, 3(3), 252–263. https://doi.org/10.24297/jac.v3i3.927

Issue

Section

Articles