https://rajpub.com/index.php/jac/issue/feed JOURNAL OF ADVANCES IN CHEMISTRY 2021-02-14T14:23:45+00:00 Editorial Office editor@rajpub.com Open Journal Systems https://rajpub.com/index.php/jac/article/view/8963 Determination of Glibenclamide By Analytical Spectrophotometry 2021-02-04T04:39:48+00:00 Saad Antakli antakli@scs-net.org Leon Nejem antakli@scs-net.org Monzer Alraii antakli@scs-net.org <p>Simple and rapid spectrophotometric method was developed and applied to determine Glibenclamide (GB) by zero spectrophotometric method and first derivative spectrophotometric method for determining of (GB) in the presence of Metformin hydrochloride (MET). Zero spectrophotometric (ZS) method was applied for the determination of (GB) at λ<sub>max</sub> = 300 nm. Linearity range was (4 – 360) μg/mL. Regression analysis showed a good correlation coefficients R<sup>2</sup> = 0.99993. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.65 μg/mL and 2.31 μg/mL, respectively. First derivative spectrophotometric (1DS) method was applied for the determination of (GB) in the presence (MET). (GB) was determined at 317 nm (1D317). Linearity ranges were (4 – 240) μg/mL for (GB). Regression analysis showed a good correlation coefficients R<sup>2</sup> = 0.999914. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.60 μg/mL and 1.83 μg/mL for (GB).</p> <p>The proposed zero spectrophotometry method was applied to analysis individual (GB), and the derivative (<sup>1</sup>D<sub>317</sub>) method was applied to analysis (GB) individually or combined with (MET) in Syrian trademark drugs.</p> <p>The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.</p> 2021-04-24T00:00:00+00:00 Copyright (c) 2021 Saad Antakli, Leon Nejem, Monzer Alraii https://rajpub.com/index.php/jac/article/view/8964 Determination of Pitavastatin Calcium by Analytical Spectrophotometry 2021-02-04T04:45:39+00:00 Saad Antakli antakli@scs-net.org Leon Nejem antakli@scs-net.org Ahmad Kullah antakli@scs-net.org <p>Simple and rapid spectrophotometric method for the quantitative analysis of Pitavastatin calcium (PTV) in raw material and tablets pharmaceutical formulation has been described. The method is based on the formation of yellow ion-pair complex between Pitavastatin calcium and Bromocresol purple (BCP) in chloroform medium.</p> <p>Different parameters affecting the reaction such as: effect of solvents, stability, reagent concentration, correlation ratio, etc. were optimized. The formed complex was quantified spectrophotometrically at absorption maximum 405 nm. Linearity range was 2.20 - 35.23 µg/mL, regression analysis showed a good correlation coefficient R<sup>2</sup> = 0.9991. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.367 µg/mL and 1.112 µg/mL respectively. The average percent recovery was found to be (100.62 – 101.14) % for Pitavastatin Calcium. This study was applied on Syrian pharmaceutical trademark: (PAVACRIUM 4 &amp; Londalop). The method was successfully applied for the determination of Pitavastatin calcium in tablets pharmaceutical formulation<strong>.</strong></p> <p>The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.</p> 2021-04-24T00:00:00+00:00 Copyright (c) 2021 Saad Antakli, Leon Nejem, Ahmad Kullah https://rajpub.com/index.php/jac/article/view/8948 Six Reasons to Discard Wave Particle Duality: Thereby Opening New Territory for Young Scientists to Explore 2021-01-14T12:35:40+00:00 Jeffrey Boyd jeffreyhboyd@gmail.com <p>Wave particle duality is a cornerstone of quantum chemistry and quantum mechanics (QM). But there are experiments it cannot explain, such as a neutron interferometer experiment. If QM uses <em>Ψ</em> as its wavefunction, several experiments suggest that nature uses -<em>Ψ</em> instead. The difference between -<em>Ψ</em> and +<em>Ψ</em> is that they describe entirely different pictures of how nature is organized. For example, with -<em>Ψ</em> quantum particles follow waves backwards, which is incompatible with wave-particle-duality, obviously. We call the -<em>Ψ</em> proposal the Theory of Elementary Waves (TEW). It unlocks opportunities for young scientists with no budget to conduct the basic research for a new, unexplored science. This is a dream come true for young scientists: the discovery of uncharted territory. We show how TEW explains the double slit, Pfleegor Mandel and Davisson Germer experiments, Feynman diagrams and the Bell test experiments. We provide innovative research designs for which -<em>Ψ</em> and +<em>Ψ</em> would predict divergent outcomes. What makes QM so accurate is its probability predictions. But Born’s law would yield the same probabilities if it were changed from <em>P</em> = |+<em>Ψ</em> |<sup>2 </sup>to <em>P</em> = |-<em>Ψ</em> |<sup>2</sup>. This article is accompanied by a lively YouTube video, “6 reasons to discard wave particle duality.”</p> 2021-02-14T00:00:00+00:00 Copyright (c) 2021 Jeffrey Boyd