Azo-Hydrazone Tautomerism and Antimicrobial activity of New substituted Imidazolines and Perimidines

Authors

  • Thoraya A Farghaly Cairo Univerisity
  • Magda A. Abdallah Cairo University, Giza, 12613
  • Mohamed R. Abdel Aziza Cairo University, Giza, 12613

DOI:

https://doi.org/10.24297/jac.v10i5.886

Keywords:

X-ray crystallography, perimidines, imidazolines, azo-hydrazone tautomerism, anti-microbial activity.

Abstract

Two new series of 2-{1-[(substitutedphenyl)-hydrazono]-2-oxo-2-phenyl-ethyl}-5,5-diphenyl-3,5-dihydro-imidazol-4-one  and  (1H-Perimidin-2-yl)-[(substitutedphenyl)-hydrazono]-acetic acid ethyl ester were prepared by coupling the diazonium salt of aniline and its derivatives with 2-(2-oxo-2-phenyl-ethylidene)-5,5-diphenyl-imidazolidin-4-one or ethyl 3-dimethylamino-2-(1H-perimidin-2-yl)-propenoate in ethanolic sodium hydroxide solution. The structures of all the newly synthesized compounds were confirmed by spectral (IR, 1H NMR, mass) spectra , and X-ray crystallographic and elemental analyses. Also, the azo-hydrazone tautomerism of these compounds was discussed. In addition, all the newly synthesized compounds were screened for their antibacterial and antifungal activity and the results obtained indicated that some of these compounds exhibited excellent activity.

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Author Biographies

Thoraya A Farghaly, Cairo Univerisity

Department of Chemistry

Magda A. Abdallah, Cairo University, Giza, 12613

Department of Chemistry, Faculty of Science

Mohamed R. Abdel Aziza, Cairo University, Giza, 12613

Department of Chemistry, Faculty of Science

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Published

2014-06-03

How to Cite

Farghaly, T. A., Abdallah, M. A., & Aziza, M. R. A. (2014). Azo-Hydrazone Tautomerism and Antimicrobial activity of New substituted Imidazolines and Perimidines. JOURNAL OF ADVANCES IN CHEMISTRY, 10(5), 2694–2704. https://doi.org/10.24297/jac.v10i5.886

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