Exocyclic enaminones as building blocks for synthesis of bioactive polyheterocyclic compounds

Authors

  • Magda A. Abdallah Cairo University, Giza, 12613
  • Thoraya A. Farghaly Cairo University, Giza, 12613
  • Mohamed R. Abdel Aziza Cairo University, Giza, 12613

DOI:

https://doi.org/10.24297/jac.v10i6.880

Keywords:

Exocyclic enaminones, heterocyclic diazonium salts, polycyclic compounds, biological activity.

Abstract

The reaction of exocyclic enaminones namely, 2-(dimethylaminomethylene)-3,4-dihydro-2H-naphthalen-1-one,  3-(dimethylaminomethylene)-thiochroman-4-one and 2-(dimethyl-aminomethylene)-indane-1,3-dione, each with heterocyclic diazonium salts afforded the respective hydrazones which undergo either in situ dehydrative cyclization or cyclized by heating with acetic acid to give polycyclic compounds. The structure of all the newly synthesized products were confirmed by elemental and spectral (IR, IH NMR, Mass) data. Also, the biological activity of some of the prepared compounds was tested against some microorganisms and promising results were obtained.

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Author Biographies

Magda A. Abdallah, Cairo University, Giza, 12613

Department of Chemistry, Faculty of Science

Thoraya A. Farghaly, Cairo University, Giza, 12613

Department of Chemistry, Faculty of Science

Mohamed R. Abdel Aziza, Cairo University, Giza, 12613

Department of Chemistry, Faculty of Science

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Published

2014-07-03

How to Cite

Abdallah, M. A., Farghaly, T. A., & Aziza, M. R. A. (2014). Exocyclic enaminones as building blocks for synthesis of bioactive polyheterocyclic compounds. JOURNAL OF ADVANCES IN CHEMISTRY, 10(6), 2753–2765. https://doi.org/10.24297/jac.v10i6.880

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Articles