Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

Authors

  • Kamelia El-Mahdy Ain Shams University, Roxy, 11711, Cairo

DOI:

https://doi.org/10.24297/jac.v4i1.960

Keywords:

Thiazolopyrimidine, Michael addition, uracil, annulation, dinucleophiles, benzodiazepine, triazepine, antitumor activity

Abstract

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

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Author Biography

Kamelia El-Mahdy, Ain Shams University, Roxy, 11711, Cairo

Department of Chemistry, Faculty of Education

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Published

2008-04-19

How to Cite

El-Mahdy, K. (2008). Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities. JOURNAL OF ADVANCES IN CHEMISTRY, 4(1), 311–317. https://doi.org/10.24297/jac.v4i1.960

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