The NMR Study and Antimicrobial Activity of Some Schiff Bases Derived From Sulphonamide Drug

Authors

  • wasfi aboud College of Veterinary Univ. of Basrah-Iraq
  • Harith Y. Mahmood College of Veterinary, University of Basrah, Iraq
  • Rasha M. Othman College of Veterinary, University of Basrah, Iraq
  • Wasan M. Shaker College of Veterinary, University of Basrah, Iraq

DOI:

https://doi.org/10.24297/jac.v12i2.2157

Keywords:

Sulfonamide, Schiff base, NMR, Antimicrobial activity, Aldehydes.

Abstract

Some Schiff base compounds derived from sulfonamide drug were synthesized by reaction of 4-aminobenzenesulfonamide with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and 2-hydroxy benzaldehyde) in good yields.  Characterization of synthesized compound was carried by elemental analysis, IR, 1H,13C, HSQC and HMBC- NMR spectroscopy. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Streptococcus sp., Bacillus subtillus, Escherichia coli and  Klebsiella pneumonia. Additionally, the compounds were tested for antifungicidal activity against Candida krusei, Candida tropicalis, Aspergillus fumigates and Aspergillus niger.  

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Author Biographies

wasfi aboud, College of Veterinary Univ. of Basrah-Iraq

Dept. of Physiolog and Chemistry

Harith Y. Mahmood, College of Veterinary, University of Basrah, Iraq

Department of Physiology and Chemistry,

Rasha M. Othman, College of Veterinary, University of Basrah, Iraq

Department of Microbiology,

Wasan M. Shaker, College of Veterinary, University of Basrah, Iraq

Department of Microbiology,

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Published

2016-12-16

How to Cite

aboud, wasfi, Mahmood, H. Y., Othman, R. M., & Shaker, W. M. (2016). The NMR Study and Antimicrobial Activity of Some Schiff Bases Derived From Sulphonamide Drug. JOURNAL OF ADVANCES IN CHEMISTRY, 12(2), 4009–4017. https://doi.org/10.24297/jac.v12i2.2157

Issue

Vol. 12 No. 2 (2016)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.