Synthesis, crystal structure and antifungal activity of dihydroisoquinoline Oxaziridines Substitued in Position 1

Authors

  • Mouna Bouzid Laboratory of Chemistry of Natural Products, Sfax University, Faculty of Science BP 1171, 3000 Sfax
  • Raed Abdennabi Laboratory of Plant Biotechnology Applied to Crop Improvement, Sfax University, Faculty of Science BP 1171, 3000 Sfax
  • Chakib Hrizi Laboratory of Materials Science and Environment, Sfax University, Faculty of Science BP 1171, 3000 Sfax
  • Neji Gharsallah Laboratory of Plant Biotechnology Applied to Crop Improvement, Sfax University, Faculty of Science BP 1171, 3000 Sfax
  • Majed Kammoun Sfax University

DOI:

https://doi.org/10.24297/jac.v10i4.893

Keywords:

Oxaziridine, m-CPBA, X-ray diffraction, Antifungal activity.

Abstract

We report here the synthesis and the X-ray crystallography of dihydroisoquinoline oxaziridines with methyl substitute in position 1 and with nitro group in position 7 (compound 3b). We also synthesized the compound 3a without nitro. These compounds have been prepared by the peracidic oxidation of imines with m-chloroperbenzoic (m-CPBA) like oxidizing agent. This two compounds exhibit higher antifungal activity.

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Author Biography

  • Majed Kammoun, Sfax University

    Chemistry, Associate Professor

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Published

2014-05-01

Issue

Vol. 10 No. 4 (2014)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Synthesis, crystal structure and antifungal activity of dihydroisoquinoline Oxaziridines Substitued in Position 1. (2014). JOURNAL OF ADVANCES IN CHEMISTRY, 10(4), 2551-2557. https://doi.org/10.24297/jac.v10i4.893

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