Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid

Authors

  • Hassen Ben Salah Laboratoire de Chimie des Substances Naturelles, Université de Sfax, Faculté des Sciences Sfax, BP 1171, 3000 Sfax
  • Maëelle Carraz Université de Toulouse; UPS; UMR 152 Pharma-DEV; Université Toulouse 3 ; Faculté des sciences pharmaceutiques; 35 Chemin des maraîchers, F-31062 Toulouse cedex 9
  • Majed Kammoun Laboratoire de Chimie des Substances Naturelles, Université de Sfax, Faculté des Sciences Sfax, BP 1171, 3000 Sfax

DOI:

https://doi.org/10.24297/jac.v10i4.5503

Keywords:

Nitrone, hydroxamic acid, cytotoxicity, Hep3B cells.

Abstract

Naturally occurring hydroxamic acid derivatives are biosynthesized by microorganisms (siderophores) and plants (benzoxazinoids). Recent developments in drug related research have highlighted the promising biological and pharmacological properties that the hydroxamic acid function may offer for the enhancement of therapeutic applications. This study reports on the full synthesis of a new dihydroisoquinoline hydroxamic acid (2-Hydroxy-3,3-dimethyl-7-nitro-3,4-dihydroisoquinolin-1(2H)-one). It also describes its cytotoxicity with regard to the human hepatocarcinoma cell line Hep3B.     

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Author Biography

Majed Kammoun, Laboratoire de Chimie des Substances Naturelles, Université de Sfax, Faculté des Sciences Sfax, BP 1171, 3000 Sfax

Chemistry, Associate Professor

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Published

2014-09-02

How to Cite

Ben Salah, H., Carraz, M., & Kammoun, M. (2014). Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid. JOURNAL OF ADVANCES IN CHEMISTRY, 10(4), 2648–2653. https://doi.org/10.24297/jac.v10i4.5503

Issue

Vol. 10 No. 4 (2014)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.

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