Coordination properties of Palladium(II) complex taken as a model of an antitumour agent with some selected amino acids, peptides and DNA constituents

Authors

  • Ayser Al-Allousi Cairo University, P.O. Box 12611
  • Perihan A. Khalf-Alla Cairo University, P.O. Box 12611
  • Safaa S. Hassan Cairo University, P.O. Box 12611
  • Mohamed M. Shoukry Faculty of Science, Chemistry Department, Cairo University, P.O. Box 12611, Egypt. Department of Chemistry, Faculty of Science, Islamic University, Madina, Saudi Arabia.

DOI:

https://doi.org/10.24297/jac.v9i3.1011

Keywords:

Coordination property, amino acids, peptides, DNA, 1, 3-diamino- 2-hydroxopropane and stability constants

Abstract

Pd(DHP)Cl2 complex ( DHP = 1,3-diamino-2-hydroxopropane ), was synthesized and characterized by physico-chemical measurements. The coordination of [Pd(DHP) (H2O)2]2+ with some selected bio-relevant ligands as phenylglycine, phenylalanine, lysine, valine, ethanolamine, glycineamide, glycylphenylalanine, glycylleucine, inosine, guanosine and inosine-5’-monophosphate disodium salt was investigated.
Stoichiometry and stability constants of the complexes formed are reported at 25 0C and 0.1M ionic strength. The results show the formation of 1:1 complexes with amino acids. DNA constituents form 1:1 and 1:2 complexes. Peptides form both 1:1 complexes and the coresponding deprotonated amide species. The effect of chloride ion concentration on the formation constant of inosine, taken as a representaive of
DNA constituents, complex with Pd(DHP)2+ was reported.

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Author Biographies

Ayser Al-Allousi, Cairo University, P.O. Box 12611

Faculty of Science, Chemistry Department

Perihan A. Khalf-Alla, Cairo University, P.O. Box 12611

Faculty of Science, Chemistry Department

Safaa S. Hassan, Cairo University, P.O. Box 12611

Faculty of Science, Chemistry Department

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Published

2013-12-01

How to Cite

Al-Allousi, A., Khalf-Alla, P. A., Hassan, S. S., & Shoukry, M. M. (2013). Coordination properties of Palladium(II) complex taken as a model of an antitumour agent with some selected amino acids, peptides and DNA constituents. JOURNAL OF ADVANCES IN CHEMISTRY, 9(3), 2046–2055. https://doi.org/10.24297/jac.v9i3.1011

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