A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

Authors

  • Dr Remon M Zaki Chemistry Dept.- Faculty of Science- 71516- Assiut University- Assiut -Egypt
  • Prof Adel M. Kamal El-Dean Chemistry Dept.- Faculty of Science- 71516- Assiut University- Assiut -Egypt
  • Dr Nermin A Marzouk Chemistry Department, Girls Faculty of Science, Al-Azhar University, Cairo, Egypt
  • Prof Jehan A Micky Chemistry Department, Girls Faculty of Science, Al-Azhar University, Cairo, Egypt
  • Mrs Rasha H Ahmed Chemistry Department, Girls Faculty of Science, Al-Azhar University, Cairo, Egypt

DOI:

https://doi.org/10.24297/jac.v12i1.845

Abstract

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

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Author Biographies

Dr Remon M Zaki, Chemistry Dept.- Faculty of Science- 71516- Assiut University- Assiut -Egypt

Citation 23, h-index 3, i-10 index 1

Prof Adel M. Kamal El-Dean, Chemistry Dept.- Faculty of Science- 71516- Assiut University- Assiut -Egypt

Citation 748, h-index 14, i-10 index 22

Published

2015-10-26

How to Cite

Zaki, D. R. M., Kamal El-Dean, P. A. M., Marzouk, D. N. A., Micky, P. J. A., & Ahmed, M. R. H. (2015). A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE. JOURNAL OF ADVANCES IN CHEMISTRY, 12(1), 3910-3918. https://doi.org/10.24297/jac.v12i1.845

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