Influence of educational program directed at patients with prehypertension and hypertension on pressure values, biochemical variables, arterial stiffness and expression of metalloproteinases 2 and 9

  • Flavia Mariana Valente Address: Av Bady Bassit 4270, ap92 T4, Vila Nossa Sra da Paz - 15025-900 - Sao Jose do Rio Preto/SP/Brazil
  • Days Oliveira de Andrade Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Cristiane Bonvicine Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Alessandra Beatriz Balduino Mendes Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Marielle Martins Borges Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Claudia Bernardi Cesarino Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Luciana Neves Cosenso Martin Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Leticia Aparecida Barufi Fernandes Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Larissa Helena Marques Carrai Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • Riccardo Lacchini
  • J. E Tanus Santos Faculdade de Medicina de Sao Jose do Rio Preto, Av Bady Bassit 4270, Sao Jose do Rio Preto - Sao Paulo, Brazil
  • J. Fernando Vilela Martin
Keywords: Hypertension, health promotion, adherence to treatment, arterial stiffness, extracellular matrix

Abstract

Considering that chronic disease treatment is seen as a challenge to health professionals, the adherence to therapy has been studied in several variables, such as socio-economic aspects, medicines, habits of daily life and food. The aim of the proposed study is to evaluate the influence of an educational program directed at patients with prehypertension and hypertension on pressure levels, biochemical variables, arterial stiffness and matrix metalloproteinase 9 (MMP-9). It is a case-control study. The participants will be allocated to three groups: 50 individuals with normal blood pressure;  80 with prehypertension; and 80 patients with hypertension in outpatient follow up with controlled blood pressure levels. Socio-demographic and behavioral data will be collected through interviews. Blood will be collected for biochemical analysis and the determination of MMP levels. Arterial stiffness will be evaluated through ambulatory blood pressure monitoring. The level of significance will be set to 5% (p<0.05).

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Author Biographies

Flavia Mariana Valente, Address: Av Bady Bassit 4270, ap92 T4, Vila Nossa Sra da Paz - 15025-900 - Sao Jose do Rio Preto/SP/Brazil

Faculdade de Medicina de São José do Rio Preto - SP

Riccardo Lacchini

Departamento de Farmacologia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo - SP

J. Fernando Vilela Martin

Departamento de Cardiologia. Faculdade de Medicina de São José do Rio Preto - SP

Published
2014-07-29
Section
Articles