Leucine: green and efficient catalyst for the synthesis of 4H-chromenes
DOI:
https://doi.org/10.24297/jac.v10i9.6168Keywords:
4H-chromene-3-carbonitrile, leucine, malononitrile, dimedone, one-pot condensationAbstract
Leucine, a naturally occurring α-amino acid, has been found as an effective catalyst to effect the one-pot three-component condensation reaction between aromatic aldehydes, malononitrile and 5,5-dimethyl-1,3-cyclohexanedione (dimedone). Various 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives are conveniently prepared by these reactions in excellent yields. High yields, short reaction times, simple work-up, use of green and naturally occurring catalyst and solvent are the main merits of the present protocol.
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References
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[12] Sarrafi Y.; Mehrasbi E.; Vahid A.; Tajbakhsh M. Chin. J. Catal. 2012, 33,1486.
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[18] Azarifar D.; Nejat-Yami R.; Sameri F.; Akrami Z. Let. Org. Chem. 2012, 9, 435.
[19] Azarifar D.; Khatami S. M; Nejat-Yami R. J. Chem. Sci. 2014, 126, 95.
[20] Fang D.; Zhang H. B.; Liu Z. L. J. Heterocycl. Chem. 2010, 47, 63.
[21] Yu L. Q.; Liu F.; You Q. D. Org. Prep. Proced. Int. 2009, 41, 77.
[22] Balalaie S.; Bararjanian M.; Sheikh-Ahmadi M. Synth. Commun. 2007, 37, 1097
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Published
2017-05-30
How to Cite
Azarifar, D., Abbasi, Y., & Badalkhani, O. (2017). Leucine: green and efficient catalyst for the synthesis of 4H-chromenes. JOURNAL OF ADVANCES IN CHEMISTRY, 10(9), 3197–3202. https://doi.org/10.24297/jac.v10i9.6168
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