Attenuation of DEN induced hepatocellular carcinoma by a novel synthesis of silver nanoparticles using Solanum villosum (Mill.) leaves

Abstract

Objective: In todays fast and furious life, the life style and food habits of people are changing drastically, due to which ninety percent of the population suffers with oxidative stress resulting as ageing process, arthritis, ischemia, neurodegeneration, chronic liver diseases and cancer. The aim of the study is to evaluate the anticancer potential of Solanum villosum leaves against the diethylnitrosamine induced experimental hepatocellular carcinoma in male wistar albino rats.Methods:Various biochemical, cancer markers, intermediatery enzymes and histopathology were studied systematically for different groups of rats. Results: The animals exposed to diethylnitrosamine showed significant alterations in all biochemical and metabolic enzymes. After administration of silver nanoparticles of Solanum villosum leaves (SNPs-AESVL 100 μg/kg b.w) effectively suppressed the tumor growth induced by diethylnitrosamine. Conclusion: Our findings suggest that silver nanoparticles of Solanum villosum leaves are potential anticancer effect, preventing tumor growth and hepatocellular damage.