Convenient one-step Synthesis of Substituted Pyrano[2,3-c]isoquinoline (2-amino-4H-chromenes) via three Component Reaction between Alkyl isocyanides and Dialkyl Acetylenedicarboxylate in the presence of 3-Hydroxyisoquinoline
DOI:
https://doi.org/10.24297/jac.v6i1.966Keywords:
4H-chromenes, alkyl isocyanides, acetylenic ester, 3-hydroxyisoquinolineAbstract
The reactive intermediate generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylate are trapped by 3-hydroxyisoquinoline to produce highly functionalized 4H-chromenes in 83-92% yields.
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Published
2010-04-10
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Convenient one-step Synthesis of Substituted Pyrano[2,3-c]isoquinoline (2-amino-4H-chromenes) via three Component Reaction between Alkyl isocyanides and Dialkyl Acetylenedicarboxylate in the presence of 3-Hydroxyisoquinoline. (2010). JOURNAL OF ADVANCES IN CHEMISTRY, 6(1), 873-877. https://doi.org/10.24297/jac.v6i1.966