Determination of Pitavastatin Calcium by Analytical Spectrophotometry

Authors

  • Saad Antakli Department of Chemistry, Faculty of Science, University of Aleppo, Syria
  • Leon Nejem Department of Chemistry, Faculty of Science, University of Aleppo, Syria
  • Ahmad Kullah Department of Chemistry, Faculty of Science, University of Aleppo, Syria

DOI:

https://doi.org/10.24297/jac.v18i.8964

Keywords:

Spectrophotometric, Pitavastatin calcium, Bromocresol purple

Abstract

Simple and rapid spectrophotometric method for the quantitative analysis of Pitavastatin calcium (PTV) in raw material and tablets pharmaceutical formulation has been described. The method is based on the formation of yellow ion-pair complex between Pitavastatin calcium and Bromocresol purple (BCP) in chloroform medium.

Different parameters affecting the reaction such as: effect of solvents, stability, reagent concentration, correlation ratio, etc. were optimized. The formed complex was quantified spectrophotometrically at absorption maximum 405 nm. Linearity range was 2.20 - 35.23 µg/mL, regression analysis showed a good correlation coefficient R2 = 0.9991. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.367 µg/mL and 1.112 µg/mL respectively. The average percent recovery was found to be (100.62 – 101.14) % for Pitavastatin Calcium. This study was applied on Syrian pharmaceutical trademark: (PAVACRIUM 4 & Londalop). The method was successfully applied for the determination of Pitavastatin calcium in tablets pharmaceutical formulation.

The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.

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Published

2021-04-24

How to Cite

Antakli, S. ., Nejem, L. ., & Kullah, A. . (2021). Determination of Pitavastatin Calcium by Analytical Spectrophotometry. JOURNAL OF ADVANCES IN CHEMISTRY, 18, 30–39. https://doi.org/10.24297/jac.v18i.8964

Issue

Vol. 18 (2021)

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Articles

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Copyright (c) 2021 Saad Antakli, Leon Nejem, Ahmad Kullah

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