Comparison Of Fe(II) And Fe(III)-Hydralazine Complexes, A Potentiometric And Spectrophotometric Studa

Authors

  • Saima Imad National Physical and Standards Laboratory (PCSIR), Islamabad
  • Muhammad Iqbal National Physical and Standards Laboratory (PCSIR), Islamabad
  • Shazia Nisar Department of Chemistry, University of Karachi
  • Shazia Ghaffar Department of Chemistry, University of Karachi

DOI:

https://doi.org/10.24297/jac.v14i1.6620

Keywords:

Ferrous, ferric, hydralazine, complex, potentiometric study, spectrophotometric Study

Abstract

Iron in oxidation states (+2 and +3) is very essential element for human body, and its concentration significantly altered in cardio vascular disease. So the aim of the present work is to study the interaction of Fe(II) and Fe(III) with very commonly used antihypertensive drug hydralazine through potentiometric and spectrophotometric methods. The objectives of the work is to study the stoichiometry, behavior of the complexes in aqueous solution, effect of pH and behavior of this drugs towards both oxidation states of Iron. Both methods show that hydralazine forms a stable complex with both oxidation states of the metal, but the nature of complex changes with change in pH, ligand concentration and with time span. Both methods confirms 1:2 stoichiometry for Fe(II)-Hydralazine while 1:3 for Fe(III)-Hydralazine. Stabilities of both complexes were also calculated. For Fe(II)-Hydralazine complex values of log β1 and log β2 were found to be 4.99 and  7.58 respectively. For Fe(III)-Hydralazine complex log β1, log β2 and log β3 values were found to be 2.74, 7.39 and 11.32 respectively. At high ligand concentration hydralazine also show reducing properties. The study suggests a strong interaction of hydralazine with iron; however the nature of interaction is different with both oxidation states of iron.

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Published

2018-01-02

How to Cite

Imad, S., Iqbal, M., Nisar, S., & Ghaffar, S. (2018). Comparison Of Fe(II) And Fe(III)-Hydralazine Complexes, A Potentiometric And Spectrophotometric Studa. JOURNAL OF ADVANCES IN CHEMISTRY, 14(1), 6046–6056. https://doi.org/10.24297/jac.v14i1.6620

Issue

Vol. 14 No. 1 (2018)

Section

Articles

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