Comparison of three types of physical aspects of a carbonated hydroxyapatite biomaterial: Study implantaion in vivo in rats of "Wistar" strain and physiological & physicochemical explorations

Authors

  • Salha Boulila Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052, Tunisia Université of Rennes 1, UMR CNRS 6226, Campus de Beaulieu, 35042 Rennes, France
  • Kais Mnafgui Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052
  • Hassane Oudadesse Université of Rennes 1, UMR CNRS 6226, Campus de Beaulieu, 35042 Rennes
  • Hafed El Feki Laboratory of Sciences Material and environment, Faculty of Sciences of Sfax, B.P. 1171, 3000 Sfax
  • Abdelfattah El Feki Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052

DOI:

https://doi.org/10.24297/jac.v8i2.4042

Keywords:

Biocompatibility, Carbonated hydroxyapatite, Oxidative stress, Subcutaneous implantation

Abstract

Currently, research on biomaterials must meet and demonstrate a set of therapeutic competence to level many health problems. The objective of our work is to normalize the technique of implantation of the biomaterial (carbonated hydroxyapatite: HAC). Three modes subcutaneous implantation was carried out. This technique consists to select the most tolerated by the body without toxicity. Thus, we have applied our biomaterial (HAC) in pellet form under pressure, under pressure sintering pellets and capsules for two weeks. Our results showed that the capsule did not disturb and mainted the equilibrium and balance or ferric ion phosphate balance, prevent against the toxicity of hepato-renal system by comparison with the pellets. These results demonstrated the tolerance, the biocompatibility and the integrity of apatite administered in capsule.

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Author Biographies

Salha Boulila, Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052, Tunisia Université of Rennes 1, UMR CNRS 6226, Campus de Beaulieu, 35042 Rennes, France

Departement of biology

Kais Mnafgui, Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052

Departement of biology

Hassane Oudadesse, Université of Rennes 1, UMR CNRS 6226, Campus de Beaulieu, 35042 Rennes

Departement of chemical

Hafed El Feki, Laboratory of Sciences Material and environment, Faculty of Sciences of Sfax, B.P. 1171, 3000 Sfax

Departement of chemical

Abdelfattah El Feki, Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3052

Departement of biology

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Published

2012-12-20

How to Cite

Boulila, S., Mnafgui, K., Oudadesse, H., El Feki, H., & El Feki, A. (2012). Comparison of three types of physical aspects of a carbonated hydroxyapatite biomaterial: Study implantaion in vivo in rats of "Wistar" strain and physiological & physicochemical explorations. JOURNAL OF ADVANCES IN CHEMISTRY, 8(2), 1612–1629. https://doi.org/10.24297/jac.v8i2.4042

Issue

Vol. 8 No. 2 (2014)

Section

Articles

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