An Efficient Isocyanide-Based Three-Component Synthesis of Novel Ketenimines
DOI:
https://doi.org/10.24297/jac.v10i3.2286Keywords:
Hexahydroacridine, acetylenedicarboxylate, isocyanide, one-potAbstract
This study provides a description of an efficient and simple procedure for the synthesis of dimethyl 2-(9-aryl)-3,3,6,6-tetramethyl-1,8-diox-1,2,3,4,5,6,7,8-octahydroacridin-10(9H)-yl)-3-((cyclohexylimino)methylene)succinate via a one-pot three-component reaction of cyclohexyl isocyanide, dimethyl acetylenedicarboxylate and hexahydroacridine-1,8(2H,5H)-dionesin CH2Cl2 at room temperature. Short reaction times, good to high yields and the novelty are the remarkable advantages of this work.
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