Synthesis of Fluorinated Pyridines as 19F NMR pH Indicators

Authors

  • Mohammad Ali Amrollahi College of Science, Yazd University, Yazd. Iran, P.O.Box 89195-741

DOI:

https://doi.org/10.24297/jac.v10i3.2275

Keywords:

Fluorination, fluorinated pyridine derivatives, 19F NMR pH indicators, pKa

Abstract

This research was undertaken to synthesizes and evaluate 3,5-dihydroxymethyl-4-(2-fluorophenyl)-2,6-dimethylpyridine and 4-(fluoromethyl)-2,6-dimethylpyridine as indicators of 19F NMR pH. A comparison of 3,5-dihydroxymethyl-4-(2-fluorophenyl)-2,6-dimethylpyridine to 4-(fluoromethyl)-2,6-dimethylpyridine showed that 4-(fluoromethyl)-2,6-dimethylpyridine has a large 19F chemical shift to pH, a suitable pKa value and a good water solubility.

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Author Biography

Mohammad Ali Amrollahi, College of Science, Yazd University, Yazd. Iran, P.O.Box 89195-741

Department of Chemistry

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Published

2014-04-04

How to Cite

Amrollahi, M. A. (2014). Synthesis of Fluorinated Pyridines as 19F NMR pH Indicators. JOURNAL OF ADVANCES IN CHEMISTRY, 10(3), 2441–2446. https://doi.org/10.24297/jac.v10i3.2275

Issue

Vol. 10 No. 3 (2014)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.