ANTIMICROBIAL EVALUATION OF MALEIMIDE MONOMERS, HOMOPOLYMERS AND COPOLYMERS CONTAINING AZO, SULPHONAMIDE AND THIAZOLE GROUPS

Abstract

New maleimide Monomers, homopolymers and copolymers  containing azo, sulfonamide and thiazole groups were synthesized. The structures of newly synthesized compounds have been characterized on the basis of their spectroscopic data (FT-IR and ¹H-NMR).  Antimicrobial studies of synthesized compounds were performed using agar well diffusion method. All the compounds showed pronounced activity against bacterial strains in comparison to activity against fungal strains.The highest antibacterial potency was exhibited by the homopolymer HPSPMI against Escherichia coli, Klebsiella pneumoniae and Bacillus subtilis.  The activity of  HPSPMI against later two was more pronounced than the standard drug used. Only Selected compounds showed antifungal activity. Appreciable results were found against Aspergillus fumigates but not with Candida albicans. HPSPMI showed highest activity against Aspergillus fumigates. Surprisingly after homo and copolymerization, maximum compounds exhibited not only pronounced antibacterial activity but also antifungal activity.