Anti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Dulce Benth Fruit Peel On Streptozotocin Induced Diabetic Rats


  • T.A. Sukantha K.S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India
  • Shubashini. K. Sripathi Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641 043, Tamil Nadu, India.
  • N. T. Ravindran Adhiparasakthi College of Arts and Science, G.B. Nagar, Kalavai – 632 506, Tamil Nadu, India.



Pithecellobium dulce fruit peel, anti-diabetic activity, streptozotocin, glibenclamide


The decoction of the Pithecellobium dulce fruit peel has been used for the control of diabetes mellitus in the traditional method adopted by the local people of northwest region of Tamil Nadu, India. The present study was carried out to investigate the anti-diabetic potential of aqueous extract of Pithecellobium dulce fruit peel by its oral administration (200 mg/kg) to streptozotocin-induced diabetic rats. The levels of blood glucose, urine sugar, glycosylated hemoglobin, glucose-6-phosphatase, fructose-1,6-bisphosphatase, total cholesterol, triglycerides, aspartate transaminase, alanine transaminase, alkaline phosphatase and reduced  glutathione were increased significantly whereas the levels of plasma insulin, hexokinase, protein, liver glycogen, reduced glutathione, superoxide dismutase, catalase and glutathione peroxidase were decreased in streptozotocin-induced diabetic rats and it was normalized after treatment of aqueous extract. Glibenclamide was used as the standard drug. These outcomes suggest that the aqueous extract possesses anti-diabetic activity and supports the traditional use of the Pithecellobium dulce fruit peel decoction as hypoglycemic agent.


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Author Biographies

T.A. Sukantha, K.S. Rangasamy College of Technology, Tiruchengode 637215, Tamil Nadu, India

Department of Chemistry,

Shubashini. K. Sripathi, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641 043, Tamil Nadu, India.

Department of Chemistry,

N. T. Ravindran, Adhiparasakthi College of Arts and Science, G.B. Nagar, Kalavai – 632 506, Tamil Nadu, India.

Department of Biochemistry,


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How to Cite

Sukantha, T., Sripathi, S. K., & Ravindran, N. T. (2016). Anti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Dulce Benth Fruit Peel On Streptozotocin Induced Diabetic Rats. JOURNAL OF ADVANCES IN CHEMISTRY, 12(15), 4807–4815.