Cd-proline Complex Catalyzed Direct one-Pot three Component Mannich Reaction in Water Medium
DOI:
https://doi.org/10.24297/jac.v7i1.970Keywords:
Cadmium-proline, Metal acetate, Mannich reaction, Water mediumAbstract
Metal-proline complexes of various metals like Zn, Cd, Hg, and Pb were found to be good catalysts for direct Mannich reaction in water medium at room temperature, smoothly affording the β-amino carbonyl compounds in excellent yields. Among the catalyst cadmium-proline complex gave high yield in lesser time. All the catalysts were easily separated from the reaction mixture by water extraction and among this cadmium -proline complex was found to be most stable and can be recycled five times without losing its catalytic activity.
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