Concise and Efficient Total Syntheses of Virenamides A and D

Authors

  • Gan Haifeng College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816
  • Chen Zhengbang College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816
  • Fang Zheng School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 211816
  • Guo Kai College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816

DOI:

https://doi.org/10.24297/jac.v4i3.945

Keywords:

Total syntheses, Virenamide, Ascidian Diplosoma virens, Thiazole

Abstract

Concise total syntheses of linear thiazole-containing peptides virenamides A (1) and D (4), isolated from Australian ascidian Diplosoma virens have been accomplished from Boc-L-valine (6) in 7 steps. A cyclization between thioamide and bromoacetaldehyde was applied to form thiazole ring as a key step.

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Published

2008-12-12

Issue

Vol. 4 No. 3 (2013)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Concise and Efficient Total Syntheses of Virenamides A and D. (2008). JOURNAL OF ADVANCES IN CHEMISTRY, 4(3), 488-493. https://doi.org/10.24297/jac.v4i3.945