Scope of Non-estrogenic Steroidal Congeners against Breast Cancer

Authors

  • Sheikh M.M Akram Islamia College of Science and Commerce, Srinagar, 190002 Department of Chemistry, University of Kashmir, Srinagar, 190002
  • G. M. Peerzadah University of Kashmir, Srinagar, 190002
  • Abid H. Banday Islamia College of Science and Commerce, Srinagar, 190002

DOI:

https://doi.org/10.24297/jac.v5i1.943

Keywords:

Estrogen receptor, Ligand binding domain, Agonist, Antagonist, SERMs

Abstract

Various novel non-estrogenic steroidal D-ring substituted analogs were synthesized and evaluated for their breast cancer activity against human breast cancer cell lines. The good cytotoxic results obtained against the breast cancer cell lines throws new insights into the field as the analogs are non 17β –Hydroxy estrogenic derivatives which are considered to be pivotal for the potent estrogenic activity. The synthesized steroidal analogs provide a very good platform for mechanistic studies of the interaction between non-esterogenic steroids and estrogen receptors.

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Author Biography

G. M. Peerzadah, University of Kashmir, Srinagar, 190002

Department of Chemistry,

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Published

2009-04-29

How to Cite

Akram, S. M., Peerzadah, G. M., & Banday, A. H. (2009). Scope of Non-estrogenic Steroidal Congeners against Breast Cancer. JOURNAL OF ADVANCES IN CHEMISTRY, 5(1), 626–632. https://doi.org/10.24297/jac.v5i1.943

Issue

Vol. 5 No. 1 (2013)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.