Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates

Authors

  • A.A. Elhenawy Chemistry Department, Faculty of Arts& Science, Albaha University, AlBaha, KSA Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
  • Mahmoud M. Abdel All Chemistry Department, Faculty of Arts& Science, Albaha University, AlBaha, KSA Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City,Cairo, Egypt
  • Abd aziz A. Alomri Albaha University, AlBaha

DOI:

https://doi.org/10.24297/jac.v10i4.895

Keywords:

Antidibeatic, ADMET, ALR2 and Thiazolidinediones

Abstract

Thiazolidinedione (1) was used as a key intermediate for the synthesis of many therapeutic anti-diabetic molecule. Thus, Thiazolidinedione (1) was refluxed with aromatic aldehydes and phenol derivatives to afforded aryldine derivative (3). Moreover, the stereochemistry for compound 3 was discussed using Hartree-Fock theory geometries, and have been optimized at HF with 6-311G level of theory. The HOMO-LUMO energy gap of studied systems has been discussed. The molecular docking simulations into the active site of ALR2 were performed, and showed that, the compound 3 more suitable inhibitor against ALR2 and can used as anti- diabetic drug.

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Author Biographies

A.A. Elhenawy, Chemistry Department, Faculty of Arts& Science, Albaha University, AlBaha, KSA Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

Chemistry Department, Faculty of Arts& Science

Abd aziz A. Alomri, Albaha University, AlBaha

Chemistry Department, Faculty of Arts& Science

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Published

2014-05-01

How to Cite

Elhenawy, A., Abdel All, M. M., & A. Alomri, A. aziz. (2014). Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates. JOURNAL OF ADVANCES IN CHEMISTRY, 10(4), 2575–2584. https://doi.org/10.24297/jac.v10i4.895

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Articles