Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates
DOI:
https://doi.org/10.24297/jac.v10i4.895Keywords:
Antidibeatic, ADMET, ALR2 and ThiazolidinedionesAbstract
Thiazolidinedione (1) was used as a key intermediate for the synthesis of many therapeutic anti-diabetic molecule. Thus, Thiazolidinedione (1) was refluxed with aromatic aldehydes and phenol derivatives to afforded aryldine derivative (3). Moreover, the stereochemistry for compound 3 was discussed using Hartree-Fock theory geometries, and have been optimized at HF with 6-311G level of theory. The HOMO-LUMO energy gap of studied systems has been discussed. The molecular docking simulations into the active site of ALR2 were performed, and showed that, the compound 3 more suitable inhibitor against ALR2 and can used as anti- diabetic drug.Downloads
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Published
2014-05-01
How to Cite
Elhenawy, A., Abdel All, M. M., & A. Alomri, A. aziz. (2014). Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates. JOURNAL OF ADVANCES IN CHEMISTRY, 10(4), 2575–2584. https://doi.org/10.24297/jac.v10i4.895
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