Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry

Authors

  • SAAD ANTAKLI Department of Chemistry, Faculty of Science, University of Aleppo, Syria
  • LEON NEJEM LEON NEJEM II (Department of Chemistry, Faculty of Science, University of Aleppo, Syria)
  • MOUSTAFA ALABO JOUMAA MOUSTAFA ALABO JOUMAA III (Department of Chemistry, Faculty of Science, University of Aleppo, Syria)

DOI:

https://doi.org/10.24297/jac.v17i.8808

Keywords:

Derivative Spectrophotometry, Hydrochlorothiazide, Atenolol

Abstract

The derivative spectrophotometric method was developed and applied for the simultaneous determination of Atenolol (ATE) and Hydrochlorothiazide (HCT) in Tablets formulations. The first derivative spectrophotometric (1DS) method was applied for the determination of (ATE) and (HCT), respectively. (ATE) was determined at 271.9 nm (1D 271.9) and (HCT) was determined at 279.3 nm (1D 279.3). Linearity showed a good correlation coefficients R2 = 0.9994 and R2 = 0.9989 for (ATE) and (HCT), respectively. Linearity ranges were (10 – 280)

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References

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British Pharmacopeia 2010.

Published

2020-09-10

How to Cite

SAAD ANTAKLI, LEON NEJEM, & MOUSTAFA ALABO JOUMAA. (2020). Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry. JOURNAL OF ADVANCES IN CHEMISTRY, 17, 73-79. https://doi.org/10.24297/jac.v17i.8808

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