Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry

Authors

  • SAAD ANTAKLI Department of Chemistry, Faculty of Science, University of Aleppo, Syria
  • LEON NEJEM LEON NEJEM II (Department of Chemistry, Faculty of Science, University of Aleppo, Syria)
  • MOUSTAFA ALABO JOUMAA MOUSTAFA ALABO JOUMAA III (Department of Chemistry, Faculty of Science, University of Aleppo, Syria)

DOI:

https://doi.org/10.24297/jac.v17i.8808

Keywords:

Derivative Spectrophotometry, Hydrochlorothiazide, Atenolol

Abstract

The derivative spectrophotometric method was developed and applied for the simultaneous determination of Atenolol (ATE) and Hydrochlorothiazide (HCT) in Tablets formulations. The first derivative spectrophotometric (1DS) method was applied for the determination of (ATE) and (HCT), respectively. (ATE) was determined at 271.9 nm (1D 271.9) and (HCT) was determined at 279.3 nm (1D 279.3). Linearity showed a good correlation coefficients R2 = 0.9994 and R2 = 0.9989 for (ATE) and (HCT), respectively. Linearity ranges were (10 – 280)

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References

Tarkase K N, Hapse S A, Shirsath A S, Kadaskar P T. Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Atenolol and Hydrochlorothiazide in Pure and Tablet Dosage Form. International Journal of Chem Tech Research. 2012; 4(3): 1146-1150.

Zaveria M, Khandharb A. Development and validation of a RP-HPLC for the simultaneous estimation of atenolol and hydrochlorothiazide in pharmaceutical dosage forms. jprhc. 2010; 2(3): 248-252.

Zaveri M , Amit K. Development and Validation of a RP-HPLC for the Simultaneous estimation of Atenolol and Hydrochlorothiazide in Pharmaceutical Dosage Forms. International Journal of Advances in Pharmaceutical Sciences .2010; 1 (2010): 167-171.

Sa'sa' S I, Jalal I M, Khalil H S. Determination of Atenolol Combinations with Hydrochlorothiazide and Chlorthalidone in Tablet Formulations by Reverse-Phase HPLC. Journal of Liquid Chromatography.2006; 11(8):1673-169.

Neelima M S, Gandhi B M, Raju V B, Sumanth K S, Mounika K S, Lakshmi P J N. Development and validation of stability indicating reverse phase high performance liquid chromatography method for simultaneous estimation of atenolol, hydrochlorothiazide and losartan in bulk and pharmaceutical dosage form. Asian J Pharm Clin Res. 2016; 9(2): 118-124.

Bari S, Sathe Sh, Jain P, Surana S. Spectrophotometric method for simultaneous estimation of atenolol in combination with losartan potassium and hydrochlorothiazide in bulk and tablet formulation. Journal of Pharmacy and Bioallied Sciences October-December. 2010; 2(4): 372-275.

Behera A K. Simultaneous Spectrophotometric Estimation of Atenolol and Hydrochlorothiazide in Tablet Dosage Forms. International Journal of Chem Tech Research. 2010; 2(4): 1901-1906.

Yadav S S, Rao J R. Micellar liquid chromatographic analysis for simultaneous determination of atenolol and hydrochlorothiazide in tablet dosage form. Int J Pharm Pharm. 2013; 5(4), 63-67.

Durga Rao D N V, Satyanarayana S S S, Ramakoti Reddy Y K, Mukkanti. Simultaneous Determination of Losartan Potassium, Atenolol and Hydrochlorothiazide in Pharmaceutical Preparations by Stability-Indicating UPLC. Chromatographia. 2009; 3(4): 647-651.

British Pharmacopeia 2010.

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Published

2020-09-10

How to Cite

SAAD ANTAKLI, LEON NEJEM, & MOUSTAFA ALABO JOUMAA. (2020). Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry. JOURNAL OF ADVANCES IN CHEMISTRY, 17, 73–79. https://doi.org/10.24297/jac.v17i.8808

Issue

Vol. 17 (2020)

Section

Articles

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Copyright (c) 2020 SAAD ANTAKLI, LEON NEJEM, MOUSTAFA ALABO JOUMAA

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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