Synthesis , Characterization and Biological activity of new derivatives of Chromen-2-one

Authors

  • Aziz Behrami

DOI:

https://doi.org/10.24297/jac.v15i1.7131

Keywords:

Chromen-2-one derivatives, streptomycine

Abstract

We report the organic syntheses of new derivatives  from Chromen-2-one and their  antibacterial activity. Compounds  4-[Acetyl-(2-oxo-2H-chromen-4-yl)-amino]-

benzenesulfonyl chloride 1a, 4-[Acetyl-(2-oxo-3-phenylsulfamoyl-2H-chromen-4-yl)-amino]-benzenesulfonyl chloride 2a , 2-{4-[Acetyl-(4-chlorosulfonyl-phenyl)-amino]-2-oxo-3-phenylsulfamoyl-2H-chromen-7-ylamino}-benzoic acid  3a.

All Structures have been synthesized and characterized using melting points , IR spectra , 1H-NMR, 13C-NMR spectra , and elemental analyses  . The purified synthesized compounds (1a,2a,3a), at contcentrations 2,3,5 mg/ml was tested for their  antibacterial activity against three bacterial cultures ;Staphylococcus aureus, Escherchia coli and Bacillus cereus. The antibacterial activity of synthesized compounds are compared with antibacterial activity of standard antibiotics cephalexine and streptomycine.  

The compounds (1a,2a,3a) shows  different bacteriostatic and bacteriocidal activity.

Downloads

Download data is not yet available.

References

1. Govori.S, Kalaj.;V, Rapic.V .; Kalaj.L.; and Dakovic .;S, Heterocycel.Commun., 2002 ; 8,129-134.
2.Stanovnik.B.; Susachitzky.H .; Scriven.E.F , Progress in Heterocyclic Chemistry, Pergamon Press ,Oxford , 1993 ; 5,75-146.
3. Lee.S.H .; Shin, D.S.; Kim.J.S .; K.-B. Oh and Kan.S.S.; Arch. Pharm. Res, 2003 ; 26-32.
4. Vyas.K.B.;NimavatK.S.; Jani.G.R.; and Hathi.M.V.; Orbital, 2009; 1, 183-189.
5. Abyshev.A.V.; GimdeinV.A.; SemenovE.V.; E.MAgevE.M.; Abdulla A.A.; Zade and Gueseinov, Pharm.Chem.J., 2006; 40.607-612.
6. Aytemir.M.D .; Hider.R.C .; Erol.D.D.; Ozalp.M and Ekizoglu.M.; Turk.J.chem., 2003 ; 27 : 445-452.
7. El.Saghier.M.M.; Naili.M.B.; Rammash.M.Kh.; Saleh.N.H.; and Kreddan.K.M.; Arkivoc, 2007;83-92.
8. Nofa.Z.M .; El-Zahar.M and Abd El Karim.;M ,Molecules, 2000 ; 5: 99-105.
9. Chaluvaraju .KC.; and Ishwarbhat .; K.Asian .; J Chem 2008 ; 20, 4335-4340.
10. Ra Kali.R .; S,Grworamma.J .; and Suresh.B .; Asian J Chem 2008 : 20: 5289-5293.
11. Mohammed Ashraf.A and Mohammed.SH.;. Boorg Med Chem. Lett 2009 ; 17: 3314-3320.
12. Nofal .ZM.; El-Zahar .M.; Abd El-Karim .S.; Novel, coumarin derivatives with expected biological activity, Molecules. 2000 ; 5: 99- 113.
13. Vyas .KB .; Nimavat. KS.; Jani .GR.; Hathi. MV.; Synthesis and microbial activity of coumarin derivatives metal complex: An in vitro evaluation.Orbital, 2009 ; 1: 183-192.

Downloads

Published

2018-03-30

How to Cite

Behrami, A. (2018). Synthesis , Characterization and Biological activity of new derivatives of Chromen-2-one. JOURNAL OF ADVANCES IN CHEMISTRY, 15(1), 6130–6135. https://doi.org/10.24297/jac.v15i1.7131

Issue

Section

Articles