Electrochemical behaviour of some alkyl substituted N-hydroxy-2,6-diarylpiperidin-4-one thiosemicarbazone and the antifungal studies of the products

Authors

  • J B Veeramalini Sriram Engineering College, Veppampattu-602024
  • G Baskar Engineering, Sriram Engineering College, Veppampattu-602024
  • N. Sheeja Engineering, Sriram Engineering College, Veppampattu-602024

DOI:

https://doi.org/10.24297/jac.v13i9.5748

Keywords:

Piperidone thiosemicarbazone, Cyclic voltammetry 1H and 13C NMR, Anti Fungal activity.

Abstract

A series of 3-ethyl-2,6-diarylpiperidin-4-one thiosemicarbazone and 3,5-dimethyl-2,6-diarylpiperidin-4-one thiosemicarbazone were synthesised. The thiosemicarbazones were subjected to cyclic voltammetric study using graphite electrode with variable scan rate at moderate acidic conditions maintained in the electrolytic solution. The reduction takes place by two electron transfer and the reaction is pH dependent. The reduced products were isolated and purified by column chromatography. The structure was proved by 1H and 13C NMR spectroscopy. The electrode process was found to be irreversible and diffusion controlled. Further the products were analysed for anti fungal activity in which nitro substituted compound showed high inhibition towards the fungi Asperillus niger

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Author Biographies

J B Veeramalini, Sriram Engineering College, Veppampattu-602024

Department of Chemical Engineering,

G Baskar, Engineering, Sriram Engineering College, Veppampattu-602024

Department of Applied Chemistry

N. Sheeja, Engineering, Sriram Engineering College, Veppampattu-602024

Department of Applied Chemistry

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Additional Files

Published

2017-02-22

How to Cite

Veeramalini, J. B., Baskar, G., & Sheeja, N. (2017). Electrochemical behaviour of some alkyl substituted N-hydroxy-2,6-diarylpiperidin-4-one thiosemicarbazone and the antifungal studies of the products. JOURNAL OF ADVANCES IN CHEMISTRY, 13(9), 6445–6455. https://doi.org/10.24297/jac.v13i9.5748

Issue

Vol. 13 No. 9 (2017)

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Articles

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