Synthesis and Antimicrobial Activity of some Novel Isoindoline-1,3-Dione Derivatives
DOI:
https://doi.org/10.24297/jac.v8i2.5570Keywords:
Phthalimide, Chalcones, Pyrazole, Pyrazoline, Antimicrobial agentsAbstract
New phthalimido derivatives incorporated with chalcone, pyrazole, pyrazoline, and pyrimidine moieties were synthesized and evaluated for their antimicrobial activities against bacterial and fungal strains. 2-{4-[1-Acetyl-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl} isoindoline-1,3-dione (7) showed broad spectrum antibacterial activity against both G+ and G- bacteria. While, (E)-2-{4-[3-(4-chlorophenyl)acryloyl]phenyl}isoindoline-1,3-dione (4b) showed promising antifungal activity.
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[7] Tetsuhashi, M., Ishikawa, M., Hashimoto, M., Hashimoto, Y., Aoyama, H., 2010, Bioorg. Med. Chem., 18, 5323.
[8] Sami, S. M., Dorr, R. T., Alberts, D. S., Solyom, A. M., Remers, W. A., 2000, J. Med. Chem., 43, 3067.
[9] Wang, J. J., Liu, T. Y., Yin, P. H., Wu, C. W., Chern, Y. T., Chi, C. W., 2000, Anticancer Res., 20, 3067.
[10] Imran, A., Waseem, A.W., Kishwar, S., Ashanul, H., 2012, Curr. Drug Ther., 7, 13.
[11] Mazzocca, A., Carloni, V., 2009,Curr. Med. Chem., 16, 1704.
[12] Ranise, A., Spallarossa, A., Cesarini, S., Bondavalli, F., Schenone, S., Bruno, O., Menozzi, G., Fossa, P., Mosti, L., Colla, M. L., Sanna, G., Murreddu, G. Collu, B. Busonera, M. E. Marongiu, A. Pani, P. L. Colla, M., Loddo, R., 2005, J. Med. Chem., 48, 3858.
[13] Ashok, P., Ganguly, S., Murugesan1, S., 2013, Der Pharma Chemica, 5(4), 10-19.
[14] Hassazadeh, F., Rabbani, M., Khodarahmi, G. A., Fasihi, A., Hakimelahi, G. H., Mohajeri, M., 2007, Res. in Pharm. Sci., 2, 35.
[15] Hirano, T., Arimitsu, J., Higa, S., Naka, T., Ogata, A., Shima, Y., Fujimoto, M., Yamadori, T., Ohkawara, T., Kuwabara, Y., Kawai, M., Kawase, I., Tanaka, T., 2006, Int. Arch. Allergy Immunol., 140, 150–156.
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[17] Zhang, X. W., Zhao, D. H., Quan, Y. C., Sun, L. P., Yin, X. M., Guan, L. P., 2010, Med. Chem. Res., 19, 403–412.
[18] Ali, M. A., Shaharyar, M., Siddiqui, A. A., 2007, Eur. J. Med. Chem., 42, 268–275.
[19] Awasthi, S. K., Mishra, N., Kumar, B., Sharma, M., Bhattacharya, A., Mishra, L. C., Bhasin, V. K., 2009, Med. Chem. Res., 18, 407–420
[20] Nowakowska, Z., Ke, B., dzia, Schroeder, G., 2008, Eur. J. Med. Chem., 43, 707–713.
[21] Gopalakrishnan, M., Thanusu, J., Kanagarajan, V., Govindaraju, R., 2009, Med. Chem. Res., 18, 341–350.
[22] Sahu, S. K., Banerjee, M., Samantray, A., Behera, C., Azam, M. A., 2008, Trop. J. Pharm. Res., 7, 961.
[23] Kalirajan, R., Sivakumar, S. U., Jubie, S., Gowramma, B., Suresh, B., 2009, Int. J. ChemTech Res., 1, 27-34.
[24] Shah, T. B., Gupte, A., Patel, M. R., Chaudhari, V. S., Patel, H., Patel, V. C., 2009, Indian J. Chem., 48B, 88.
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[26] Cockerill, F.R., Wikler, M. A., Bush, K., Dudley, M. N., Eliopoulos, G. M., Hardy, D. J., Hecht, D. W., Hindler, J. A., Patel, J. B., Powell, M., Thomson, R. B., Weinstein, M. P., Zimmer, B. L., Ferraro, M. J., Swenson, J. M., 2009, Clinical and Laboratory Standards Institute (CLSI Document M100-S19), 30.
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Published
2008-03-02
How to Cite
Lamie, P. F. (2008). Synthesis and Antimicrobial Activity of some Novel Isoindoline-1,3-Dione Derivatives. JOURNAL OF ADVANCES IN CHEMISTRY, 8(2), 1660–1666. https://doi.org/10.24297/jac.v8i2.5570
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