One-Pot Multicomponent Synthesis of Novel 2-Thioxo-Benzo[6,7]Chromeno[2,3d]Pyrimidin-4-one Derivatives using Cetylpyridinium Chloride

Abstract

The novel 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivatives were prepared by one pot multicomponent condensation reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol in acetonitrile-water as solvent using surfactant, cetylpyridinium chloride (CPC) at water bath temperature in good yields. The structures of the compounds were confirmed by elemental analyses and spectral data.