Synthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives

Abstract

Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by   FT-IR, ¹H-NMR, ¹³C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC₅₀ = 62.2 µg/ml) and 4b (IC₅₀ = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC₅₀ = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation