Ultrasound-promoted synthesis of novel dihydropyrido[2,3-d:5,6- d`]dipyrimidine derivatives

Authors

  • Manouchehr Mamaghani Faculty of Sciences, Islamic Azad University, Rasht Branch, P.O. Box 41335-3516,Rasht

DOI:

https://doi.org/10.24297/jac.v11i5.4475

Keywords:

6-amino-2-(alkylthio)pyrimidin-4(3H)-one, pyrido[2, 3-d]pyrimidine, ultrasonic irradiation, three-component reaction.

Abstract

An efficient synthesis of dihydropyrido[2,3-d:5,6-d`]pyrimidine derivatives was developed via one-pot three-component reaction of 6-amino-2-(alkylthio)-pyrimidine-4(3H)one and aryl aldehydes in the mixed solvent of glacial acetic acid and DMF (1:1, v:v) under ultrasonic irradiation. In this protocol novel fused dihydropyrido[2,3-d]pyrimidines were synthesized in high yields (80-97%) and lower reaction times (5-25 min).

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Author Biography

Manouchehr Mamaghani, Faculty of Sciences, Islamic Azad University, Rasht Branch, P.O. Box 41335-3516,Rasht

Department of Chemistry

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Published

2015-04-18

How to Cite

Mamaghani, M. (2015). Ultrasound-promoted synthesis of novel dihydropyrido[2,3-d:5,6- d`]dipyrimidine derivatives. JOURNAL OF ADVANCES IN CHEMISTRY, 11(5), 3567–3575. https://doi.org/10.24297/jac.v11i5.4475

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