Effect of Trifluoromethyl Substitution on C-3 Position in 1H NMR of Quinolones / Coumarins

Authors

  • Anjali Gupta I.T.S. Engineering College, Greater Noida, U.P. University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector-16C, Dwarka, New Delhi-110078
  • Rajinder K. Gupta University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector-16C, Dwarka, New Delhi-110078

DOI:

https://doi.org/10.24297/jac.v8i3.4053

Keywords:

NMR, 1H, trifluoromethyl, quinolones, coumarins

Abstract

The structural assignment of differently substituted quinolones / coumarins was reviewed using 1H NMR spectral data. In case of quinolones / coumarins, with varied substitutions at C-4 and different positions of the benzenoid ring, there is a great variation in the 1H NMR value of the proton only attached with C-3. It was observed that when different substitutions (methyl / amino / hydroxy / acetoxy / trifluoromethyl) were carried out at C-4 position, maximum deshielding with the proton attached with C-3 was observed with trifluoromethyl substitution. The observation is same even with the variation in different groups at the benzenoid ring. 

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Published

2016-12-21

How to Cite

Gupta, A., & Gupta, R. K. (2016). Effect of Trifluoromethyl Substitution on C-3 Position in 1H NMR of Quinolones / Coumarins. JOURNAL OF ADVANCES IN CHEMISTRY, 8(3), 1707–1715. https://doi.org/10.24297/jac.v8i3.4053

Issue

Vol. 8 No. 3 (2014)

Section

Articles

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Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.