Clinical Utility of Melatonin in Fibromyalgia Diagnosis

Authors

  • Ali M. El-Sayed Yousef Benha Teaching Hospital, Benha
  • Sherry K. Abd El-Rahman Benha Teaching Hospital, Benha
  • Hatem A. EL-Mezayen Helwan University, Helwan
  • Eman R. Amer (PhD) Benha Teaching Hospital, Benha
  • Shimaa Sabry Damietta University, Damietta
  • Camelia A. Abdel-Malak Damietta University, Damietta

DOI:

https://doi.org/10.24297/jac.v8i3.4057

Keywords:

Fibromyalgia syndrome (FMS), Melatonin (MT), Widespread pain index (WPI) and symptom severity (SS) scale.

Abstract

       Fibromyalgia syndrome (FMS) is a chronic disease with an unknown etiology, which is characterized by reduced pain threshold (hyperallgesia) & pain with normally innocuous stimuli (allodynia).This diffuse pain is often disease associated  with wide range of  other symptoms including fatigue, sleep disturbance, stiffness& more.FMS often occur concomitantly  with other rheumatologic disease such as rheumatoid arthritis(RA), systemic lupus erthymatosus(SLE).

       The pineal hormone melatonin (MT) exerts a variety of effects on the immune system. MT activates immune cells and enhances inflammatory cytokine and nitric oxide production.

Methods:

 We were studied 75 subjects, 55 of subjects were FMS patients defined by the American Colleague of Rheumatology (ACR 2010) criteria. Patients' mean age was 32.5 ± 13.9 years. They were classified into two groups: Group I of 25  primary FMS patients . Group II of 30 secondary FMS patients with other rheumatologic disease such as RA, SLE. Twenty age and sex matched healthy individuals were included in the study as a control group.

Results:

Mean Melatonin titers were significantly reduced (p<0.0001) in primary FMs patients compared to the controls (21.32vs. 30.9 pg/ml), but they were significantly elevated (p<0.0001) in secondary FMS compared to controls (138.1vs.30.9 pg/ml). Our data imposed that, in 1ry FMS there were negative correlations of MT titers with tender points (r=-0.848**,p<0.0001), sleep disturbance(r=-0.963**, p< 0.0001**), Fatigue (r= -0.972**, p<0.001**), WPI (r= -0,953 **, p<0.0001) and SS (r=-0.901**, p< 0.0001).

 Conclusions:

In primary FMS patients melatonin level is lower than melatonin level in control, but MT level is high in secondary FMS patients. There was a negative correlation between MT with tender points, sleep disturbance, fatigue, SS & WPI. But there was a positive correlation between MT & cognitive symptoms.

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Author Biographies

Ali M. El-Sayed Yousef, Benha Teaching Hospital, Benha

Departments of Internal Medicine

Sherry K. Abd El-Rahman, Benha Teaching Hospital, Benha

Rheumatology and Rehabilitation

Hatem A. EL-Mezayen, Helwan University, Helwan

Department of Chemistry, Biochemistry Division, Faculty of Science

Eman R. Amer (PhD), Benha Teaching Hospital, Benha

Department of Clinical Pathology

Shimaa Sabry, Damietta University, Damietta

Department of Chemistry,  Biochemistry Division, Faculty of Science

Camelia A. Abdel-Malak, Damietta University, Damietta

Department of Chemistry,  Biochemistry Division, Faculty of Science

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Published

2016-12-21

How to Cite

Yousef, A. M. E.-S., El-Rahman, S. K. A., EL-Mezayen, H. A., Amer (PhD), E. R., Sabry, S., & Abdel-Malak, C. A. (2016). Clinical Utility of Melatonin in Fibromyalgia Diagnosis. JOURNAL OF ADVANCES IN CHEMISTRY, 8(3), 1765–1775. https://doi.org/10.24297/jac.v8i3.4057

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