Analytical Study for the Charge-Transfer Complexes of Risperidone in Pure and Dosage Forms

Authors

  • F. Ibrahim Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.
  • N. El-Enany Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.
  • Sh. Shalan Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.
  • Rasha Mostafa Elsharawy Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.

DOI:

https://doi.org/10.24297/jac.v8i3.4055

Keywords:

Spectrophotometric, charge transfer, Risperidone, chloranilic acid and tetracyanoquinodimethane.

Abstract

Two simple, accurate and sensitive spectrophotometric methods were carried out to investigate through charge-transfer reactions of risperidone (RIS) as n-electron donor with various π acceptors: 7, 7, 8, 8-tetracyanoquinodimethane (TCNQ) and p-chloranilic acid (pCA). The absorbance of reaction product was measured at 842 and 520 nm for TCNQ and pCA reagents respectively. Different experimental parameters affecting the reactions were carefully studied. The reaction pathway was postulated. The proposed spectrophotometric method was utilized for the analysis of RIS in pure form as well as in its pharmaceutical preparations. Under the optimum reaction conditions, Beer’s law is obeyed over the concentration range of 1-12 µg mL-1 and 10-180 µg mL-1 for TCNQ and pCA respectively. The limit of assays detection (LOD) is 0.114 µg mL-1 and 2.55 µg mL-1 for TCNQ and pCA respectively. The mean recovery percentage was 99.72 ± 1.06 and 100.50 ± 1.07 for TCNQ and pCA respectively. The results were compared favorably with those obtained by comparison method. The proposed method was validated statistically according to ICH guidelines.

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Author Biographies

F. Ibrahim, Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.

Departement of analytical chemistry

N. El-Enany, Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.

Departement of analytical chemistry

Sh. Shalan, Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.

Departement of analytical chemistry

Rasha Mostafa Elsharawy, Faculty of pharmacy, University of Mansoura 35516, Mansoura, Egypt.

Departement of analytical chemistry

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Published

2016-12-21

How to Cite

Ibrahim, F., El-Enany, N., Shalan, S., & Elsharawy, R. M. (2016). Analytical Study for the Charge-Transfer Complexes of Risperidone in Pure and Dosage Forms. JOURNAL OF ADVANCES IN CHEMISTRY, 8(3), 1745–1753. https://doi.org/10.24297/jac.v8i3.4055

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