Synthesis and Antimicrobial Evaluation of Some New Benzoxazinone and Quinazolinone Derivatives

Authors

  • Assy M.G. Chemistry Department, Faculty of Science, Zagazige University
  • Abdalha A.A. Chemistry Department, Faculty of Science, Ain shams University, Abassia, Cairo, Egypt Current address, Chemistry Department, Faculty of Science, Tabuk University, KSA
  • Abdel Aziz A.E Zagazige University, Current address, Chemistry Department, Faculty of Science, Tabuk University

DOI:

https://doi.org/10.24297/jac.v8i1.4030

Keywords:

Benzoxazinone, Quinazolinone, Benzoimidazolone, Triazole, Tetrazole

Abstract

Ring opening reactions of benzoxazinone (2) with nitrogen and oxygen nucleophiles gave the corresponding benzamides (3)&(4) and benzoates (5).Quinazolinone derivatives (6) and (7) were obtained upon treatment of (2) with hydrazine hydrate and/or hydroxylamine hydrochloride.Triazole derivatives (8a – b) were obtained when (2) was subjected to react with semicarbazide and/or thiosemicarbazide respectively. Reaction of (2) with sodium azide gave a mixture of tetrazole derivative (9) and benzoimidazolone derivative (10). The antimicrobial activity of  some synthesized compounds was examined against bacteria, fungi and yeast. Some of the tested compounds showed promising activities.

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Author Biography

Abdel Aziz A.E, Zagazige University, Current address, Chemistry Department, Faculty of Science, Tabuk University

Chemistry Department, Faculty of Science

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Published

2016-12-20

How to Cite

M.G., A., A.A., A., & A.E, A. A. (2016). Synthesis and Antimicrobial Evaluation of Some New Benzoxazinone and Quinazolinone Derivatives. JOURNAL OF ADVANCES IN CHEMISTRY, 8(1), 1491–1499. https://doi.org/10.24297/jac.v8i1.4030

Issue

Vol. 8 No. 1 (2014)

Section

Articles

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Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.