Design, Synthesis and Antibacterial Evaluation of some new 3,5-Diphenylcyclohex-2-en-1-one Derivatives

Authors

  • Ahmed M. El-Saghier Sohag University, Sohag 82524, Sohag
  • Omyma A. Abd Allah Sohag University, Sohag 82524, Sohag
  • Asmaa M. Kadry Sohag University, Sohag 82524, Sohag

DOI:

https://doi.org/10.24297/jac.v6i1.5538

Keywords:

Diphenylcyclohexene, Chromen, PTC, Benzothiazole, Antibacterial activity

Abstract

The moiety of cyclohexene has been showed highly antibacterial activity. New compounds were synthesized from diphenylcyclohexenone via reaction with a variety of reagents to afford branched chain of 1,3-diphenylcyclohexene or fused heterocyclic systems including pyrazole, chromen and pyrrole derivatives. Cyclic ketoketene s,s-acetal can be prepared by reaction with CS2/MeI under PTC conditions which in turn used as starting material for the synthesis of pyrazolyl and benzothiszolyl derivatives. Most of new synthesized compounds were characterized by using spectral data and were screened for their antibacterial activity.

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Author Biographies

Ahmed M. El-Saghier, Sohag University, Sohag 82524, Sohag

Chemistry Department, Faculty of Science

Omyma A. Abd Allah, Sohag University, Sohag 82524, Sohag

Chemistry Department, Faculty of Science

Asmaa M. Kadry, Sohag University, Sohag 82524, Sohag

Chemistry Department, Faculty of Science

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Published

2013-12-22

How to Cite

El-Saghier, A. M., A. Abd Allah, O., & M. Kadry, A. (2013). Design, Synthesis and Antibacterial Evaluation of some new 3,5-Diphenylcyclohex-2-en-1-one Derivatives. JOURNAL OF ADVANCES IN CHEMISTRY, 6(1), 923–929. https://doi.org/10.24297/jac.v6i1.5538

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