Synthesis of 2, 3-Dihydro-1,4-naphthaquinone Derivatives for Targeting the Altered Cancer Cells Metabolism

Authors

  • Mohammed Hassan Mohammed College of Pharmacy,Baghdad University, Baghdad
  • Monther Faisal Mahdi College of Pharmacy, University of AI-mustansiriyah
  • Fadhil Mohsin Hamed College of Pharmacy, Baghdad University, Baghdad, Iraq

DOI:

https://doi.org/10.24297/jac.v4i2.2708

Keywords:

Anticancer, proudrug, 2, 3-Dihydro-1, 4-naphthaquinone, bromopyrovic acid, N-acetyl cysteine, 5-fluorouracil, 6-Mercaptopurine

Abstract

A new four derivatives of 2,3-Dihydro-1,4-naphthaquinonewere synthesizedas possible bioreductiveprodrugs for5-fluorouracil (5-Fu),Mercaptopurine (6-MP), N-acetyl cysteine (NAC)and 3-bromopyrovic acid (3-BPA) to selectively deliver the drugs into the cancer cells and these are:2-((5-fluoro-1,2-dihydropyrimidin-4-yloxy)methyl)-3-hydroxy naphthalene-1,4dione(compound A),2-((9H-purin-6-ylthio)-3-hydroxyl naphthalene-1,4dione(compound B)acetmido-3-((3-methyl-1,4-dihydronaphthalen-2-yl)methylthio)propanoicacid (compound C)and hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl3-bromo-2-oxopropanoate ( compound D)Their chemical structures were characterized by H1 NMR, IR spectroscopy and elemental microanalysis.The in vitro antitumor activity tests againstHep-2 human larynx    cancer cell lineindicated that compound A,B,C and D havesignificant  anticancer activities when compared with 5-Fu.

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Author Biographies

Mohammed Hassan Mohammed, College of Pharmacy,Baghdad University, Baghdad

Assist.prof. Department of pharmaceutical chemistry

Monther Faisal Mahdi, College of Pharmacy, University of AI-mustansiriyah

Department of pharmaceutical chemistry

Fadhil Mohsin Hamed, College of Pharmacy, Baghdad University, Baghdad, Iraq

Department of pharmaceutical chemistry

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Published

2008-08-08

How to Cite

Mohammed, M. H., Mahdi, M. F., & Hamed, F. M. (2008). Synthesis of 2, 3-Dihydro-1,4-naphthaquinone Derivatives for Targeting the Altered Cancer Cells Metabolism. JOURNAL OF ADVANCES IN CHEMISTRY, 4(2), 472–481. https://doi.org/10.24297/jac.v4i2.2708

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