Kinetic and Conventional Spectrophotometric Determination of Bumadizone in its Tablets via Oxidative Coupling with 3-Methyl-2-Benzothiazolinone Hydrazone

Authors

  • Mohamed Walash University of Mansoura , 35516, Mansoura
  • Fathalla Belal University of Mansoura , 35516, Mansoura
  • Manar Tolba University of Mansoura , 35516, Mansoura
  • Mohamed Halawa University of Mansoura , 35516, Mansoura

DOI:

https://doi.org/10.24297/jac.v5i3.2680

Keywords:

Bumadizone, MBTH, Kinetic, Oxidative coupling, Pharmaceutical analysis.

Abstract

Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of bumadizone in bulk drug and its tablets. Both methods based on the oxidative coupling reaction with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) and measuring the absorbance of the developed colors by direct or kinetic spectrophotometric method. Upon treatment of a mixture of the chromogenic reagent and drug with cerium (IV) ammonium sulfate (method I) or ferric chloride (method I), a red or violet color was developed immediately or after 30 minutes measurable at 557 nm for method I or II, respectively. The absorbance-concentration plots were rectilinear over the ranges of 1-10 μg/mL (r = 0.9999) for method I and 2-16 μg/mL (r = 0.9998) for method II. The detection limits were  0.15 and 0.27 μg/mL & the quantitation limits were 0.46 and 0.84 μg/mL for methods I and II, respectively. Different experimental parameters affecting the development and stability of the reactions products were studied and optimized. The proposed methods were applied successfully to the determination of bumadizone in its tablets, and the results obtained were in good agreement with those obtained using a comparison  method. 

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Author Biographies

Mohamed Walash, University of Mansoura , 35516, Mansoura

Department of Analytical Chemistry, Faculty of  Pharmacy

Fathalla Belal, University of Mansoura , 35516, Mansoura

Department of Analytical Chemistry, Faculty of  Pharmacy

Manar Tolba, University of Mansoura , 35516, Mansoura

Department of Analytical Chemistry, Faculty of  Pharmacy

Mohamed Halawa, University of Mansoura , 35516, Mansoura

Department of Analytical Chemistry, Faculty of  Pharmacy

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Published

2009-12-02

How to Cite

Walash, M., Belal, F., Tolba, M., & Halawa, M. (2009). Kinetic and Conventional Spectrophotometric Determination of Bumadizone in its Tablets via Oxidative Coupling with 3-Methyl-2-Benzothiazolinone Hydrazone. JOURNAL OF ADVANCES IN CHEMISTRY, 5(3), 839–854. https://doi.org/10.24297/jac.v5i3.2680

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