4-(3,4-Dichlorophenyl)-6-(Furan-2-yl)Pyrimidine-2-Thiol as Building Block in Heterocyclic Synthesis

DOI:

https://doi.org/10.24297/jac.v5i2.2656

Keywords:

Hydrazinylpyrimidine, Oxadiazolo-pyrimidine, Pyrazolo-pyrimidine, Thioxopyrimidine, Triazolo-pyrimidine.

Abstract

Pyrimidine-2-thiol (1) has been synthesized via one-pot, three component synthesis. Its behavior towards nitrogen nucleophiles like hydrazine hydrate, ethylamine, piperidine, and 2-aminobenzoic acid has been studied. A speculation to explain the activities of the thioamide-iminothiol equilibrium based on their thermodynamic and kinetic control under the experimental conditions were investigated. The hydrazinopyrimidine 2 and aminocarbamoyl derivative 8 were used as key starting materials for synthesis of some interesting nitrogen bridgehead compounds 10-13, hydrazones 14-16, and some mixed and non-mixed heterocyclic systems 17-19 respectively.

Downloads

Download data is not yet available.

Published

2009-09-17

How to Cite

4-(3,4-Dichlorophenyl)-6-(Furan-2-yl)Pyrimidine-2-Thiol as Building Block in Heterocyclic Synthesis. (2009). JOURNAL OF ADVANCES IN CHEMISTRY, 5(2), 669-677. https://doi.org/10.24297/jac.v5i2.2656

Issue

Section

Articles