Cytotoxic Activity of Secondary Metabolites from the Bark of Dipterocarpus Confertus Sloot

Abstract

Four compounds, namely β-sitosterol (1), betulinic acid (2), cinnamic acid (3), and α-viniferin (4) have been successfully isolated from the bark methanol extract of Dipterocarpus confertus Sloot. The structures of the isolated compounds have been established on the basis spectroscopic data evidence, and comparison with the published data. In the cytotoxicity study, cinnamic acid (3) and betulinic acid (2) have been found to be very strong active against murine leukemia P388 and vero cells lines with the IC₅₀ values of 2.25 and 5.10 µg/mL, respectively, while the other compounds were not active.