Spectrophotometric Assay of some Nitrogen Containing Drugs in Pharmaceutical Formulations using p-Chloranilic Acid Reagent

Authors

  • Theia’a N. Al-Sabha College of Education, University of Mosul
  • Mahmood A. Hasan University of Duhok
  • Huda A. Ibrahim University of Duhok

DOI:

https://doi.org/10.24297/jac.v9i1.2299

Keywords:

Spectrophotometry, p-Chloranilic acid, Sulfacetamide sodium, Lidocaine, Terbutaline sulfate

Abstract

A spectrophotometric method is developed for the determination of some drugs containing amino groups (sulfacetamide sodium, lidocaine and terbutaline sulfate) based on their reaction with p-chloranilic acid reagent in an organic medium forming colored charge transfer complexes. The complexes have maximum absorptions at 530 and 527 nm for sulfacetamide sodium and lidocaine respectively, but terbutaline sulfate gave two maximum absorptions at 529 and 319 nm. Beers law is obeyed over the concentration range of 10-60 µg.ml-1 for sulfacetamide sodium and lidocaine and 5-70 µg.ml-1 for terbutaline sulfate. The molar absorptivity values are 0.94—103, 0.913—103 L.mol-1.cm-1 for sulfacetamide sodium and lidocaine respectively while terbutaline sulfate gave 0.987—103 L.mol-1.cm-1 at 529 nm and 7.407—103 L.mol-1.cm-1 at 319 nm with accuracy range between 100.20% and 101.42% and RSD better than 3.15% for all drugs. The method is applied successfully for determination of these drugs in pharmaceutical formulations and compared favorably with British Pharmacopeia standard methods. F and t tests are less than the tabulated values at 95% confidence level.

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Author Biographies

Theia’a N. Al-Sabha, College of Education, University of Mosul

Department of Chemistry

Mahmood A. Hasan, University of Duhok

Department of Chemistry, Faculty of Science

Huda A. Ibrahim, University of Duhok

Department of Chemistry, Faculty of Science

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Published

2013-01-01

How to Cite

Al-Sabha, T. N., A. Hasan, M., & A. Ibrahim, H. (2013). Spectrophotometric Assay of some Nitrogen Containing Drugs in Pharmaceutical Formulations using p-Chloranilic Acid Reagent. JOURNAL OF ADVANCES IN CHEMISTRY, 9(1), 1798–1809. https://doi.org/10.24297/jac.v9i1.2299

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