SYNTHESIS AND CHARACTERIZATION OFGOLDNANOPARTICLESUSING CEFOTAXIMSODIUM AND ITS SCHIFF BASE DERIVATIVE WITH 4-N,N-DIMETHYLAMINO BENSALDEHYDEAS REDUCING ANDSTABILIZING AGENTS

Abstract

Conjugated GNPs were synthesized  by one step reaction of AuCl₄^- with   cefotaxim  (CFX) and its Schiff base derivative with 4-N,N-dimethylamino benzaldehyde [sodium 3-(acetoxymethyl)-7-((2Z)-2-(2-(4-dimethylamino) benzylideneamino) thiazol-4-yl)-2-(methoxyimino) acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate] (SCFX)without the need of  reducing and functionalizing agents. The reduction process was monitored by uv-visible spectrophotometry  and the synthesized GNPs were characterized by TEM, SEM, AFM and  XRD analysis. The conjugation of GNPs with the two ligands was characterized by FTIR spectrophotometry. The size, morphology, and stability of GNPs were varied with concentration ratio of ligand/Au(III), pH medium and reaction temperature