SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF POLYMER NICKEL (II) COMPLEX

Abstract

4-vinyl pyridine nickel complex containing polymerizable vinyl group, prepared by condensing (4:1 molar ratio) of 4-vinyl

pyridine with Nickel chloride, then polymerized with methyl methacrylate at 70 °C using AIBN as initiator. Metal complex

and polymer metal complex have been characterized by elemental analyses, molar conductance, IR, 1H-NMR , Mass

spectra and thermal analyses (DTA and TGA). Conductivity measurement reveals the nonelectrolytic nature of the

complex. This confirms that, the anion is coordinated to the metal ion. The IR reveal the metal ion is coordinated via the

nitrogen atom of 4-VP. Nickel complex and polymer nickel complex have been tested invitro against number of tumor and

number of microorganisms in order to assess their anti tumor and antimicrobial properties. The antimicrobial activity was

observed by compounds VP-Ni and MMA-VP-Ni under the screening conditions. The activity against HCT-116 cells was

detected for compound VP-Ni (with IC50 value 9.8±0.6 µg/ml), compared with reference standard (24.6±0.3 µg/ml) followed

by MMA-VP-Ni (48.3±1.5). In conclusion, this study highlighted the synthesis of polymer nickel complex, and proved the

promising biological activity of the synthesized compounds.