Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects

Authors

  • magda hassan abdellattif magda H. Abdellattif

DOI:

https://doi.org/10.24297/jac.v12i4.2175

Keywords:

molecular docking, pyridones, anticancer, microwave

Abstract

Introduction: A green protocol will be used to synthesize a novel series of 3-cyano-5- arylazo-pyridones (9a-c) and (10d-i).

Methodology: Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, NMR) as well as alternative synthetic routes, anticancer cell-line will be investigated and also molecular docking studies will be applied.

Results: The activity against different cancer cell-line will be studied. Compounds with electron withdrawal group showed the highest activities.

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Author Biography

magda hassan abdellattif, magda H. Abdellattif

Deanship of scientific research, Taif university

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Published

2016-12-16

How to Cite

abdellattif, magda hassan. (2016). Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects. JOURNAL OF ADVANCES IN CHEMISTRY, 12(4), 4351–4364. https://doi.org/10.24297/jac.v12i4.2175

Issue

Vol. 12 No. 4 (2016)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.