Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects

Abstract

Introduction: A green protocol will be used to synthesize a novel series of 3-cyano-5- arylazo-pyridones (9_a-c) and (10_d-i).

Methodology: Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, NMR) as well as alternative synthetic routes, anticancer cell-line will be investigated and also molecular docking studies will be applied.

Results: The activity against different cancer cell-line will be studied. Compounds with electron withdrawal group showed the highest activities.