Beneficial Effect of Zinc on diabetes induced kidney damage and liver stress oxidative in rats
DOI:
https://doi.org/10.24297/jab.v10i1.6022Keywords:
Diabetic rats, zinc, liver, kidney, stress oxidantAbstract
The present study was designed to investigate the effects of Zn supplementation on kikney function and liver oxidative stress in Alloxan diabetic rats. Male albino Wistar rats were randomly divided into 4 groups (n=10): Control, Non Diabetic + zinc, Diabetic and Diabetic + Zinc. Diabetes was induced by alloxan (150 mg/kg). Zinc (231 mg/kg feed) as ZnSO4 7H2O was added to the feed of the animals in the zinc groups for 21 days. Alloxan Diabetes caused a significant decrease in body weight gain, serum and tissue zinc, serum protein concentrations, liver GSH, GPx and GST activities .In contrast, it led to an augmentation in urea, creatinine, uric acid and MDA in rats. Zinc supplementation in the diet for diabetic rats ensured a partial correction of the previous parameters. In conclusion, this study indicated that zinc act as powerful antioxidants which may exercise adverse effect against severity and complication of diabetes.
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References
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[26] El-Missiry M.A., 1999. Enhanced testicular antioxidant system by ascorbic acid in alloxane diabetic rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , 124, 233–237.
[27] Derouiche S. and Djouadi A. 2016. An evaluation of stress oxidative and serum electrolytes in female hypothyroid patients. world journal of pharmacy and pharmaceutical sciences. 6(3),17-26.
[28] Boussekine.S. and Bouzerna, N. 2013. Effect of Selenium on Cardiovascular Diseases in Alloxan
Induced Diabetic Rats European Journal of Scientific Research., 116(3),294-301.
[29] Mariani, E., Mangialasche, F.m Feliziani, F.T., Cecchetti, R., Malavolta, M., Bastiani, P., Baglioni, M., Dedoussis, G., Fulop, T., Herbein, G., Jajte, J., Monti ,D., Rink, L., Mocchegiani, E. and Mecocci ,P. 2008. Effects of Zinc supplementation on antioxidant enzyme activities in
healthy old Subjects. Exp. Gerontol. 43(5):445.
[30] Ani, M., Moshtaghie, A.A. and Aghadavood, M. 2007. Protective effects of selenium and zinc
on the brain acetyl cholinerterase activity in lead intoxified rat. Res. Pharm. Sci. 2:80-84.
[2] Bouillon, R. 1991.Diabetic bone disease.calcified tissue international.springer. 49, 155-160
[3] Alberto, Y., Wayhs, C., Maria T., Barros, H. and Regla, V. 2015. Modulation in Diabetic Encephalopathy-Related Depression. Current Pharmaceutical Design,; 21, 4980-4988
[4] Vaag, A., P. Dmsbo, O. Hother-Nielsen and H. Beck- Nielsen, 1992. Hyperglycemia compensates for the
defects in insulin mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin dependent) diabetes mellitus. Diabetologia, 35: 80-88.
[5] Gavin, N., Levinthal, M.D, and Anthony S.and Tavill. 1999. Liver Disease and Diabetes Mellitus. clinical diabetes.17(2):
[6] T.Z. Min, M.W. Stephens, P. Kumar, and R.A. Chudleigh. 2012.Renal complications of diabetes. British Medical Bulletin; 104, 113–127
[7] Qi, Sun, Rob, M., van D., Walter, C., Willett, and Frank B. 2009. Prospective Study of Zinc Intake and Risk of Type 2 Diabetes in Women. Diabetes Care; 32, 629-634.
[8] Jayawardena, R., Ranasinghe, P., Galappatthy, P., Malkanthi ,R.L.DK, Constantine, G.R, and P Katulanda. 2012. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr.; 4, 13.
[9] MadubunyiI f.i, Onoja S. and Asuzu, I. 2012. In vitro antioxidant and in vivo antidiabetic potential of the methanol extract of Ficusglumosa Del (Moraceae) stem bark in alloxan-induced diabetic mice. Comp Clin Path.; 21, 389-394.
[10] Butrimovitz Gerald P. and Purdy William C. 1977. The determination of zinc in blood plasma by atomic absorption spectrometry, Anal Chim Acta; 94,63-73.
[11] Sastre, J., Pallardo, F.V., Asuncion, J., Vina, J., 2000. Mitochondria, oxidative stress and aging. Free. Radic. Res. 32(3), 189-198.
[12] Weckbercker, G., Cory, J.G ., 1988. Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro. Cancer Letters 40(3), 257-264.
[13] Habig, W.H., Pabst, M.J. and Jakoby, W.B., 1974. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem 249, 7130-7139.
[14] Flohe, L. and Gunzlerm, 1984Assays of glutathione peroxidase. Methods Enzymol.; 105,114-121.
[15] AI Abayomi, E.O., Adewoye, S.B., Olaleye, and Salami, A.T. 2011. Effect of Magnesium pre-treatment on Alloxan induced hyperglycemia in rats. Afr Health Sci. 11(1): 79–84.
[16] Haidari F., , ShahiMajid, M., Zarei M., , Rafiei H. and Omidian K. 2012. Effect of green tea extract on body weight, serum glucose and lipid profile in Streptozotocin-induced diabetic rats. Saudi Med J. 33 (2): 128-133.
[17] Laleh, P, Alireza O, Majid M, et al. 2013. Effects of zinc supplementation on the anthropometric measurements, Lipid profiles and fasting blood Glucose in the healthy obese adults. Adv Pharm Bull. 3, 161-165.
[18] Parvaneh N.A, Parichehr H, Shokofeh G. 2009. Effect of Zinc Supplement on the Upper and Lower Trunk Strength on Athletics Women. Res. J. Int. Stud. 9, 59-64.
[19] Ajibola, R.S, Ogundahunsi, O.A, Soyinka OO, et al. 2014. Serum Chromium, Molybdenum, Zinc and Magnesium Levels in Diabetes Mellitus Patients in Sagamu, South West Nigeria. asia j med sci. 6(2), 15-19.
[20] Sharif, Philip Thomas, Peter Zalewski and Michael Fenech. 2015. Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. MolNutr Food Res. 59(6), 1200–12.
[21] Jayawardena, R., Ranasinghe, P., Galappatthy P, Malkanthi RLDK, Constantine GR and Katulanda P. 2012. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. DiabetolMetabSyndr., 4(1),13
[22] Grodsky, G.M. and Schmid, Y.F. 1985. Kinetic and quantitative relationship between insulin release and 65Zn efflux from perfused islet. Endocrinology; 117(2), 704-710.
[23] T.Z. Min M.W. Stephens P. Kumar R.A. Chudleigh. 2012. Renal complications of diabetes.Br Med Bull 104 (1), 113-127.
[24] Gross JL, Azevedo MJ, Silveiro SP, et al. 2005. Diabetic nephropathy: Diagnosis, prevention and treatment. Diabetes Care. 28,164–76.
[25] Soto, C.P., Perez, B.L., Favari, L.P., Reyes, J.L., 1998. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 119,125– 129.
[26] El-Missiry M.A., 1999. Enhanced testicular antioxidant system by ascorbic acid in alloxane diabetic rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol , 124, 233–237.
[27] Derouiche S. and Djouadi A. 2016. An evaluation of stress oxidative and serum electrolytes in female hypothyroid patients. world journal of pharmacy and pharmaceutical sciences. 6(3),17-26.
[28] Boussekine.S. and Bouzerna, N. 2013. Effect of Selenium on Cardiovascular Diseases in Alloxan
Induced Diabetic Rats European Journal of Scientific Research., 116(3),294-301.
[29] Mariani, E., Mangialasche, F.m Feliziani, F.T., Cecchetti, R., Malavolta, M., Bastiani, P., Baglioni, M., Dedoussis, G., Fulop, T., Herbein, G., Jajte, J., Monti ,D., Rink, L., Mocchegiani, E. and Mecocci ,P. 2008. Effects of Zinc supplementation on antioxidant enzyme activities in
healthy old Subjects. Exp. Gerontol. 43(5):445.
[30] Ani, M., Moshtaghie, A.A. and Aghadavood, M. 2007. Protective effects of selenium and zinc
on the brain acetyl cholinerterase activity in lead intoxified rat. Res. Pharm. Sci. 2:80-84.
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Published
2017-04-17
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Derouiche, S., Manel, D., & Kawther, A. (2017). Beneficial Effect of Zinc on diabetes induced kidney damage and liver stress oxidative in rats. JOURNAL OF ADVANCES IN BIOLOGY, 10(1), 2050–2055. https://doi.org/10.24297/jab.v10i1.6022
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