Study of Apelin Serum Levels in patients with Hepatitis C virus Chronic Liver Disease.

Authors

  • Moustafa Bakrey Ata Faculty of Medicine, Menoufia University, Menoufia
  • Tarek El-Mahdy Korah Faculty of Medicine, Menoufia University, Menoufia
  • Gasser Ibrahim El-Azab National liver institute, Menoufia University, Menoufia
  • Eman Abd El-Fatah Badr Faculty of Medicine, Menoufia University, Menoufia
  • Khaled Mohamed Amin El-Zorkany Faculty of Medicine, Menoufia University, Menoufia

DOI:

https://doi.org/10.24297/jab.v7i2.4564

Keywords:

apelin, insulin resistance, liver fibrosis, steatosis and hepatitis C virus (HCV).

Abstract

Objective: The aim was to study the apelin serum levels and assessment of insulin resistance role in chronic liver diseased patients.

Background: Apelin is involved in many physiological and pathological function in human, it is thought to increase liver fibrosis progression with the aid of insulin resistance. There is a significant association of insulin resistance and apelin level and liver progression.

Materials and methods: This study was carried at Internal Medicine Department and National Liver Institute, Menoufia University Hospitals, from the period of January 2014 to October 2014. Subjects were classified into 5 groups each group contained 15 subjects: Group (I) served as healthy control of matched sex and age, Group (II) had liver steatosis without HCV infection, Group (III) had HCV-related liver steatosis, Group (IV) had HCV-related liver fibrosis and Group (V) had HCV-related liver cirrhosis.

Results: Serum apelin level was elevated in liver steatosis, fibrosis and it was significantly higher in cirrhotic patients. Insulin resistance correlate positively with serum apelin and liver disease progression.

Conclusion: Serum apelin is significantly higher in patients with HCV-liver cirrhosis compared to HCV-related liver fibrosis and steatosis that say, apelin plays a role in progression of liver disease and inhibition of the apelinergic system could offer new therapeutic opportunities against liver complication. A strong relation between insulin resistance and apelin on one side and other side between insulin resistance and liver fibrosis progression.

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Author Biographies

Moustafa Bakrey Ata, Faculty of Medicine, Menoufia University, Menoufia

Internal medicine

Tarek El-Mahdy Korah, Faculty of Medicine, Menoufia University, Menoufia

PhD Internal medicine

Gasser Ibrahim El-Azab, National liver institute, Menoufia University, Menoufia

MD Internal medicine

Eman Abd El-Fatah Badr, Faculty of Medicine, Menoufia University, Menoufia

MD Medical biochemistry

Khaled Mohamed Amin El-Zorkany, Faculty of Medicine, Menoufia University, Menoufia

MD Internal medicine

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Published

2015-05-07

How to Cite

Ata, M. B., Korah, T. E.-M., El-Azab, G. I., El-Fatah Badr, E. A., & Amin El-Zorkany, K. M. (2015). Study of Apelin Serum Levels in patients with Hepatitis C virus Chronic Liver Disease. JOURNAL OF ADVANCES IN BIOLOGY, 7(2), 1260–1267. https://doi.org/10.24297/jab.v7i2.4564

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Articles