The use of Aglepristone in the treatment of pregnancy related diabetic ketoacidosis: description of a case in a bitch

Authors

  • Daniela Callegari Private Practitioner, Parma
  • Carla Bresciani Department of Veterinary Science University of Parma Italy
  • Ezio Bianchi Department of Veterinary Science University of Parma Italy
  • Valeria De Cesaris Department of Veterinary Science University of Parma Italy
  • Enrico Parmigiani Department of Veterinary Science University of Parma Italy
  • Virginia Bigaran Department of Veterinary Science University of Parma Italy
  • Enrico Bigliardi Department of Veterinary Science University of Parma Italy

DOI:

https://doi.org/10.24297/jaa.v4i3.5057

Keywords:

Aglepristone, insulin resistance, gestational diabetes mellitus, dog.

Abstract

Gestational diabetes mellitus (GDM) is a rare disease in dogs that depends from an endogenous insulin supply that is insufficient to meet the tissues demands for the action of diabetogenic molecules like progesterone (P4), estradiol, growth hormone (GH), placental lactogen and placental cytokines. This report describes for the first time a case of GDM complicated by ketoacidosis treated with the P4 receptor blocker aglepristone. In our case aglepristone seemed to increase insulin sensitivity, helping in the resolution of ketoacidosis and of diabetes mellitus. Aglepristone may represent an effective and well tolerated therapeutic option in case of GDM.

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JOURNAL OF ADVANCES IN AGRICULTURE

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Published

2015-07-16

How to Cite

Callegari, D., Bresciani, C., Bianchi, E., De Cesaris, V., Parmigiani, E., Bigaran, V., & Bigliardi, E. (2015). The use of Aglepristone in the treatment of pregnancy related diabetic ketoacidosis: description of a case in a bitch. JOURNAL OF ADVANCES IN AGRICULTURE, 4(3), 487–491. https://doi.org/10.24297/jaa.v4i3.5057

Issue

Vol. 4 No. 3 (2015)

Section

Articles

License

Creative Commons License All articles published in Journal of Advances in Linguistics are licensed under a Creative Commons Attribution 4.0 International License.

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