TY - JOUR AU - SAAD ANTAKLI, AU - LEON NEJEM, AU - MOUSTAFA ALABO JOUMAA, PY - 2020/09/10 Y2 - 2024/03/29 TI - Simultaneous Determination Of Atenolol And Hydrocholrothiazide In Tablets Formulation By Derivative Spectrometry JF - JOURNAL OF ADVANCES IN CHEMISTRY JA - JAC VL - 17 IS - SE - Articles DO - 10.24297/jac.v17i.8808 UR - https://rajpub.com/index.php/jac/article/view/8808 SP - 73-79 AB - <p>The derivative spectrophotometric method was developed and applied for the simultaneous determination of Atenolol (ATE) and Hydrochlorothiazide (HCT) in Tablets formulations. The first derivative spectrophotometric (<sup>1</sup>DS) method was applied for the determination of (ATE) and (HCT), respectively. (ATE) was determined at 271.9 nm (<sup>1</sup>D <sub>271.9</sub>) and (HCT) was determined at 279.3 nm (<sup>1</sup>D <sub>279.3</sub>). Linearity showed a good correlation coefficients R<sup>2</sup> = 0.9994 and R<sup>2</sup> = 0.9989 for (ATE) and (HCT), respectively. Linearity ranges were (10 – 280) ER -