TY - JOUR AU - Zaki, Dr Remon M AU - Kamal El-Dean, Prof Adel M. AU - Marzouk, Dr Nermin A AU - Micky, Prof Jehan A AU - Ahmed, Mrs Rasha H PY - 2015/10/26 Y2 - 2024/03/29 TI - A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE JF - JOURNAL OF ADVANCES IN CHEMISTRY JA - JAC VL - 12 IS - 1 SE - Articles DO - 10.24297/jac.v12i1.845 UR - https://rajpub.com/index.php/jac/article/view/845 SP - 3910-3918 AB - <p> Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile <strong>1</strong> in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds <strong>3a-d</strong> underwent <em>Thorpe-Ziegler</em> cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds <strong>4a-d</strong>, while the other compounds <strong>3e,f</strong> failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound <strong>7-16</strong>. All the newly synthesized compounds were established by elemental and spectral analysis (IR, <sup>1</sup>H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.</p> ER -